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  Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse.

Sakaba, T., & Neher, E. (2001). Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse. Neuron, 32, 1119-1131.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F6F2-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-D140-D
Genre: Journal Article

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600051.pdf (Publisher version), 219KB
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 Creators:
Sakaba, T.1, Author              
Neher, E.2, Author              
Affiliations:
1Research Group of Biophysics of Synaptic Transmission, MPI for biophysical chemistry, Max Planck Society, ou_578583              
2Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: In many synapses, depletion and recruitment of releasable synaptic vesicles contribute to use-dependent synaptic depression and recovery. Recently it has been shown that high- frequency presynaptic stimulation enhances recovery from depression, which may be mediated by Ca2+. We addressed this issue by measuring quantal release rates at the calyx of Held synapse and found that transmission is mediated by a heterogeneous population of vesicles, with one subset releasing rapidly and recovering slowly and another one releasing reluctantly and recovering rapidly. Ca2+ promotes refilling of the rapidly releasing synaptic vesicle pool and calmodulin inhibitors block this effect. We propose that calmodulin- dependent refilling supports recovery from synaptic depression during high-frequency trains in concert with rapid recovery of the slowly releasing vesicles.

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Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
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 Identifiers: eDoc: 233879
Other: 34723
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 32 Sequence Number: - Start / End Page: 1119 - 1131 Identifier: -