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  Molecular beacons: nucleic acid hybridization and emerging applications

Antony, T., & Subramaniam, V. (2001). Molecular beacons: nucleic acid hybridization and emerging applications. Journal of Biomolecular Structure and Dynamics, 19, 497-504.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0012-F742-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002A-0E71-B
Genre: Journal Article

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600090.pdf (Publisher version), 260KB
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 Creators:
Antony, T.1, Author              
Subramaniam, V.1, Author              
Affiliations:
1Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society, ou_578628              

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Free keywords: Triple-helix formation; C-src protooncogene; Real-time detection; Mycobacterium-tuberculosis; Antisense therapeutics; Multiplex detection; Promoter region; Living cells; DNA; Probes
 Abstract: Molecular beacons (MBs) are a novel class of nucleic acid probes that become fluorescent when bound to a complementary sequence. Because of this characteristic, coupled with the sequence specificity of nucleic acid hybridization and the sensitivity of fluorescence techniques, MBs are very useful probes for a variety of applications requiring the detection of DNA or RNA. We survey various applications of MBs, including the monitoring of DNA triplex formation, and describe recent developments in MB design that enhance their sensitivity.

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Language(s): eng - English
 Dates: 2005-08-182001
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 237995
Other: 34669
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Title: Journal of Biomolecular Structure and Dynamics
  Alternative Title : J. Biomol. Struct. Dyn.
Source Genre: Journal
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Pages: - Volume / Issue: 19 Sequence Number: - Start / End Page: 497 - 504 Identifier: -