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  Released Fraction and Total Size of a Pool of Immediately Available Transmitter Quanta at a Calyx Synapse

Schneggenburger, R., Meyer, A. C., & Neher, E. (1999). Released Fraction and Total Size of a Pool of Immediately Available Transmitter Quanta at a Calyx Synapse. Neuron, 23(2), 399-409. doi:10.1016/S0896-6273(00)80789-8.

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Schneggenburger, R.1, Autor           
Meyer, A. C.2, Autor           
Neher, E.2, Autor           
Affiliations:
1Research Group of Synaptic Dynamics and Modulation, MPI for Biophysical Chemistry, Max Planck Society, ou_578582              
2Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Zusammenfassung: The size of a pool of readily releasable vesicles at a giant brainstem synapse, the calyx of Held, was probed with three independent approaches. Using simultaneous pre- and postsynaptic whole-cell recordings, two forms of presynaptic Ca2+ stimuli were applied in rapid succession: uncaging of Ca2+ by flash photolysis and the opening of voltage-gated Ca2+ channels. The ensuing transmitter release showed a nearly complete cross-inhibition between the two stimuli, indicating the depletion of a limited pool of about 700 transmitter quanta. The pool size was confirmed in experiments using enhanced extracellular Ca2+ concentrations, as well as short, high-frequency stimulus trains. The results reveal a surprisingly large pool of functionally available vesicles, of which a fraction of about 0.2 is released by a single presynaptic action potential under physiological conditions.

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Sprache(n): eng - English
 Datum: 1999-06
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/S0896-6273(00)80789-8
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Titel: Neuron
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 23 (2) Artikelnummer: - Start- / Endseite: 399 - 409 Identifikator: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565