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  Usefulness and limitations of linear approximations to the understanding of Ca++ signals

Neher, E. (1998). Usefulness and limitations of linear approximations to the understanding of Ca++ signals. Cell Calcium, 24(5-6), 345-357. doi:10.1016/S0143-4160(98)90058-6.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-FDA4-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-7525-7
Genre: Journal Article
Other : Usefulness and limitations of linear approximations to the understanding of Ca++ signals

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Neher, E.1, Author           
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1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: Simple approximations to some limiting cases of Ca++ signalling provide insight into the complex problems of buffered diffusion and of Ca++ homeostasis in the presence of buffers. Three cases are presented, where the influence of Ca++ buffers can readily be understood in the limit of small signals: the return of global cellular [Ca++] following a short stimulus in a ‘Single Compartment’, buffered diffusion along a cylindrical axon in the ‘Rapid Buffer Approximation’, and nonequilibrium microdomains of elevated [Ca++] in the immediate vicinity of open Ca++ channels.

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Language(s): eng - English
 Dates: 1998
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/S0143-4160(98)90058-6
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Title: Cell Calcium
Source Genre: Journal
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Publ. Info: Amsterdam, Netherlands : Elsevier
Pages: - Volume / Issue: 24 (5-6) Sequence Number: - Start / End Page: 345 - 357 Identifier: ISSN: 0143-4160
CoNE: https://pure.mpg.de/cone/journals/resource/954922647086