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  Swelling-induced catecholamine secretion recorded from single chromaffin cells

Moser, T., Chow, R. H., & Neher, E. (1995). Swelling-induced catecholamine secretion recorded from single chromaffin cells. Pflügers Archiv: European Journal of Physiology, 431(2), 196-203. doi:10.1007/BF00410191.

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BF00410191.pdf (Publisher version), 888KB
 
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Moser, T.1, Author           
Chow, R. H.1, Author           
Neher, E.1, Author           
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1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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Free keywords: cell swelling; exocytosis; chromaffin cells
 Abstract: We have studied osmotically induced catecholamine secretion from bovine adrenal chromaffin cells by combining patch-clamp measurements, electrochemical detection of secretion, and Fura-2 measurements of intracellular free calcium concentration ([Ca2+]i). We find that osmotically induced catecholamine release is exocytotic and calcium dependent. Furthermore, we demonstrate that cell swelling is coupled to such secretion via a volume-activated current, carrying predominantly chloride, which causes a plateau depolarization of the cell membrane potential and thus promotes voltage-activated calcium influx. Therefore, cell volume changes may modulate the secretory activity.

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Language(s): eng - English
 Dates: 1995-12
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF00410191
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Title: Pflügers Archiv: European Journal of Physiology
  Other : Pflügers Arch. Europ. J. Physiol.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 431 (2) Sequence Number: - Start / End Page: 196 - 203 Identifier: ISSN: 0031-6768
CoNE: https://pure.mpg.de/cone/journals/resource/954925432380