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  Fractional contribution of calcium to the cation current through glutamate receptor channels

Schneggenburger, R., Zhou, Z., Konnerth, A., & Neher, E. (1993). Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron, 11(1), 133-143. doi:10.1016/0896-6273(93)90277-X.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-072C-2 Version Permalink: https://hdl.handle.net/21.11116/0000-000C-9150-5
Genre: Journal Article

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1-s2.0-089662739390277X-main.pdf (Publisher version), 2MB
 
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Schneggenburger, R., Author
Zhou, Z.1, Author           
Konnerth, A.2, Author           
Neher, E.3, Author           
Affiliations:
1Abteilung Kinetik der Phasenbildung, MPI for biophysical chemistry, Max Planck Society, ou_578549              
2Research Group of Cellular Neurophysiology, MPI for biophysical chemistry, Max Planck Society, ou_578557              
3Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: The Ca2+ fraction of the ion current flowing through glutamatergic NMDA and AMPA/kainate receptor channels was determined in forebrain neurons of the medial septum. The neurons were overloaded with the Ca2+ indicator dye fura-2 (1 mM) via the recording patch pipettes. This approach allowed the direct determination of the Ca2+ influx from changes in the Ca2+-sensitive fura-2 fluorescence. We found that, at negative membrane potentials and at an extracellular free Ca2+ concentration of 1.6 mM, the Ca2+ fraction of the current through the NMDA receptor channels is only 6.8%, about 2-fold lower than previously estimated from reversal potential measurements. Interestingly, a quite high fractional Ca2+ current of 1.4% was determined for the linearly conducting AMPA/kainate receptor channels found in these neurons.

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Language(s): eng - English
 Dates: 1993-07
 Publication Status: Issued
 Pages: -
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0896-6273(93)90277-X
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 11 (1) Sequence Number: - Start / End Page: 133 - 143 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565