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  Phase transition from a gel to a fluid phase of cubic symmetry in dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) bilayers.

Heimburg, T., Ryba, N., Wuerz, U., & Marsh, D. (1990). Phase transition from a gel to a fluid phase of cubic symmetry in dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) bilayers. Biochimica et Biophysica Acta, 1025(1), 77-81. doi:10.1016/0005-2736(90)90192-Q.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0DB2-6 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-36F5-F
Genre: Journal Article

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602974.pdf (Publisher version), 430KB
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Heimburg, T.1, Author              
Ryba, N.2, Author              
Wuerz, U.3, Author              
Marsh, D.2, Author              
Affiliations:
1Research Group of Biophysics and Thermodynamics of Membranes, MPI for biophysical chemistry, Max Planck Society, ou_578546              
2Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society, ou_578624              
3Abteilung Kinetik der Phasenbildung, MPI for biophysical chemistry, Max Planck Society, ou_578549              

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 Abstract: Aqueous dispersions (pH 4.0) of a 2:1 (mol/mol) mixture of myristic acid with dimyristoylphosphatidylcholine undergo a sharp transition at 45–47°C from a lamellar gel phase to a fluid phase which is optically isotropic. This fluid phase gives rise to 31P-NMR spectra, and 2H-NMR spectra of the chain-deuterated components, which are also isotropic. X-ray diffraction studies of the fluid phase at 49°C, reveal reflections with spacings in the ratio √2: (√3): √4: √6: √8, accompanied by a strong diffuse scatter. These reflections index on a cubic lattice of primitive space group Pn3 or Pn3m, or possibly the body-centered group Im3m, with a lattice constant of 21.2 nm. The dimensions of the phase are consistent with a structure composed of two systems of tetrahedrally (octahedrally) oriented inverted lipid cylinders, found for other cubic lipid phases with Pn3m (Im3m) symmetry. At higher temperatures the cubic phase gradually converts, with increasing temperature, to a coexisting inverted hexagonal phase.

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Language(s): eng - English
 Dates: 1990-06-11
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Biochimica et Biophysica Acta
Source Genre: Journal
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Pages: - Volume / Issue: 1025 (1) Sequence Number: - Start / End Page: 77 - 81 Identifier: ISSN: 0006-3002