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  Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.

Grupe, A., Schroter, K. H., Ruppersberg, J. P., Stocker, M., Drewes, T., Beckh, S., et al. (1990). Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO Journal, 9(6), 1749-1756.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0DB8-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-37C1-C
Genre: Journal Article

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 Creators:
Grupe, A., Author
Schroter, K. H., Author
Ruppersberg, J. P., Author
Stocker, M., Author
Drewes, T., Author
Beckh, S.1, Author              
Pongs, O.2, Author              
Affiliations:
1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              
2Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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 Abstract: We have isolated and characterized a human cDNA (HBK2) that is homologous to novel member (RCK2) of the K+ channel RCK gene family expressed in rat brain. RCK2 mRNA was detected predominantly in midbrain areas and brainstem. The primary sequences of the HBK2/RCK2 K+ channel proteins exhibit major differences to other members of the RCK gene family. The bend region between segments S1 and S2 is unusually long and does not contain the N-glycosylation site commonly found in this region. They might be O-glycosylated instead. Functional characterization of the HBK2/RCK2 K+ channels in Xenopus laevis oocytes following micro-injection in in vitro transcribed HBK2 or RCK2 cRNA showed that the HBK2/RCK2 proteins form voltage-gated K+ channels with novel functional and pharmacological properties. These channels are different to RCK1, RCK3, RCK4 and RCK5 K+ channels.

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Language(s): eng - English
 Dates: 1990-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 285386
ISI: A1990DF98000009
 Degree: -

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Title: EMBO Journal
Source Genre: Journal
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Pages: - Volume / Issue: 9 (6) Sequence Number: - Start / End Page: 1749 - 1756 Identifier: ISSN: 0261-4189