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  Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice.

Kessel, M., Balling, R., & Gruss, P. (1990). Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell, 61(2), 301-308. doi:10.1016/0092-8674(90)90810-2.

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603009.pdf (Publisher version), 7MB
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Kessel, M.1, Author           
Balling, R.1, Author           
Gruss, P.1, Author           
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1Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

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 Abstract: To understand the function of murine homeobox genes, a genetic analysis is mandatory. We generated gain-of-function mutants by introducing genomic sequences of the Hox-1.1 gene under the control of a chicken beta-actin promoter into mice. Our previous data had shown that these transgenic mice are nonviable after birth and are born with craniofacial abnormalities. In a subsequent detailed analysis of severely affected animals, malformations of the basioccipital bone, the atlas, and the axis were observed. Manifestation of an additional vertebra, a proatlas, occurred at the craniocervical transition. The dominant interference of the Hox-1.1 transgene with developmental programs seems to occur around day 9 of gestation, the time of neural crest migration and somite differentiation. We discuss the resulting phenotype with respect to a developmental control function of Hox-1.1.

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Language(s): eng - English
 Dates: 1990-04-20
 Publication Status: Issued
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 61 (2) Sequence Number: - Start / End Page: 301 - 308 Identifier: ISSN: 0092-8674