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  Differential expression of sodium channel mRNAs in rat peripheral nervous system and innervated tissues.

Beckh, S. (1990). Differential expression of sodium channel mRNAs in rat peripheral nervous system and innervated tissues. FEBS Letters, 262(2), 317-322. doi:10.1016/0014-5793(90)80218-8.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0E18-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3717-E
Genre: Journal Article

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603025.pdf (Publisher version), 743KB
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 Creators:
Beckh, S.1, Author              
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1Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578579              

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 Abstract: RNA blot hybridization analyses using probes specific for sodium channels I, II and III revealed high levels of sodium channel I mRNA and low levels of sodium channel II and III mRNAs in peripheral nervous system (PNS) tissues. The developmental expression patterns of these mRNAs were generally similar to those described for the central nervous system. The small amounts of sodium channel I and III mRNAs present in tongue muscle were greatly reduced after partial denervation. Expression of the three sodium channels thus appears to be restricted to the nervous system. Putative novel additional mRNAs, specifically expressed in the PNS, were detected with a probe that recognizes nucleotide sequences common to sodium channels I, II and III.

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Language(s): eng - English
 Dates: 1990-03-26
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: FEBS Letters
Source Genre: Journal
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Pages: - Volume / Issue: 262 (2) Sequence Number: - Start / End Page: 317 - 322 Identifier: ISSN: 0014-5793