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  Watching G proteins at work.

Uhl, R., Wagner, R., & Ryba, N. (1990). Watching G proteins at work. Trends in Neurosciences, 13(2), 64-70. doi:10.1016/0166-2236(90)90070-Q.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-0E6C-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-3856-7
Genre: Journal Article

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603067.pdf (Publisher version), 848KB
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 Creators:
Uhl, R.1, Author              
Wagner, R.1, Author              
Ryba, N.2, Author              
Affiliations:
1Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society, ou_578620              
2Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society, ou_578624              

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 Abstract: It has been known for over a century that rod photoreceptors in the living retina contract and swell in response to light. Although it is still not known whether this structural light-response is of any functional significance, it has recently been possible to correlate the underlying molecular processes with the activation and deactivation of the photoreceptor G protein, transducin. The technique of light-scattering allows the monitoring of minute changes in cell dimensions, and using this non-invasive experimental approach it can be shown that certain properties of the coupling between transducin and rhodopsin are different in a structurally well-preserved system as compared with rod material used for conventional biochemical studies. Thus, not unlike a psychiatrist, who often learns more about a patient's 'interiors' by observing the body language than by direct interrogation, a biochemist, studying the 'body language' of a cell, may extract information about delicate 'cell interior processes' that would be perturbed by more direct experimental approaches.

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Language(s): eng - English
 Dates: 1990-02
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Trends in Neurosciences
Source Genre: Journal
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Pages: - Volume / Issue: 13 (2) Sequence Number: - Start / End Page: 64 - 70 Identifier: ISSN: 0166-2236