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  Intra- and interspecific variation in primate gene expression patterns

Enard, W., Khaitovich, P., Klose, J., Zoellner, S., Heissig, F., Giavalisco, P., et al. (2002). Intra- and interspecific variation in primate gene expression patterns. Science, 296(5566), 340-343. Retrieved from http://www.sciencemag.org/cgi/reprint/296/5566/340.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-9429-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-F127-7
Genre: Journal Article

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17034.pdf (Publisher version), 0B
 
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 Creators:
Enard, W.1, Author
Khaitovich, P.1, Author
Klose, J., Author
Zoellner, S.1, Author
Heissig, F.1, Author
Giavalisco, P.1, Author
Nieselt-Struwe, K.2, Author              
Muchmore, E., Author
Varki, A., Author
Ravid, R., Author
Doxiadis, G. M., Author
Bontrop, R. E., Author
Paeaebo, S., Author
Affiliations:
1Max Planck Society, Max Planck Society              
2Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578585              

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 Abstract: Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional get electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.

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Language(s): eng - English
 Dates: 2002-04-12
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 296 (5566) Sequence Number: - Start / End Page: 340 - 343 Identifier: -