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  Identification of tissue-specific microRNAs from mouse

Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Current Biology, 12(9), 735-739. Retrieved from http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6VRT-45X0D1F-N-8&_cdi=6243&_user=38661&_pii=S0960982202008096&_origin=search&_coverDate=04%2F30%2F2002&_sk=999879990&view=c&wchp=dGLbVzW-zSkzS&md5=b97c58758586f91c8a12a4f8ef46f9e0&ie=/sdarticle.pdf.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-94EF-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0029-D6B5-C
Genre: Journal Article

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Lagos-Quintana, M.1, Author              
Rauhut, R.2, Author              
Yalcin, A.2, Author              
Meyer, J.1, Author              
Lendeckel, W.1, Author              
Tuschl, T.1, Author              
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1Research Group of Combinatorical Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578556              
2Department of Cellular Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578576              

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 Abstract: MicroRNAs (miRNAs) are a new class of noncoding RNAs, which are encoded as short inverted repeats in the genomes of invertebrates and vertebrates [1, 2]. It is believed that miRNAs are modulators of target mRNA translation and stability, although most target mRNAs remain to be identified. Here we describe the identification of 34 novel miRNAs by tissue- specific cloning of approximately 21-nucleotide RNAs from mouse. Almost all identified miRNAs are conserved in the human genome and are also frequently found in nonmammalian vertebrate genomes, such as pufferfish. In heart, liver, or brain, it is found that a single, tissue-specifically expressed miRNA dominates the population of expressed miRNAs and suggests a role for these miRNAs in tissue specification or cell lineage decisions. Finally, a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.

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Language(s): eng - English
 Dates: 2002-04-30
 Publication Status: Published in print
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 Rev. Method: Peer
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Title: Current Biology
Source Genre: Journal
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Pages: - Volume / Issue: 12 (9) Sequence Number: - Start / End Page: 735 - 739 Identifier: -