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  A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM)

Mazziotta, J. C., Toga, A. W., Evans, D. J., Fox, P., Lancaster, J., Zilles, K., et al. (2001). A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM). Philosophical Transactions of the Royal Society of London - Series B, Biological Sciences, 356, 1293-1322. doi:10.1098/rstb.2001.0915.

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Mazziotta, John C., Author
Toga, A. W., Author
Evans, D. J., Author
Fox, Peter, Author
Lancaster, J., Author
Zilles, Karl, Author
Woods, Roger P., Author
Paus, Thomas, Author
Simpson, G., Author
Pike, B., Author
Holmes, C., Author
Collins, L., Author
Thomson, P., Author
MacDonald, D., Author
Iacoboni, Marco, Author
Schormann, T., Author
Amunts, Katrin, Author
Palomero-Gallagher, N., Author
Geyer, Stefan1, Author              
Parsons, Lawrence, Author
Narr, K., AuthorKabani, N., AuthorLe Goualher, G., AuthorBoomsma, D., AuthorCannon, T., AuthorKawashima, R., AuthorMazoyer, B., Author more..
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1External Organizations, ou_persistent22              

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 Abstract: Motivated by the vast amount of information that is rapidly accumulating about the human brain in digital form, we embarked upon a program in 1992 to develop a four-dimensional probabilistic atlas and reference system for the human brain. Through an International Consortium for Brain Mapping (ICBM) a dataset is being collected that includes 7000 subjects between the ages of eighteen and ninety years and including 342 mono- and dizygotic twins. Data on each subject includes detailed demographic, clinical, behavioural and imaging information. DNA has been collected for genotyping from 5800 subjects. A component of the programme uses post-mortem tissue to determine the probabilistic distribution of microscopic cyto- and chemoarchitectural regions in the human brain. This, combined with macroscopic information about structure and function derived from subjects in vivo, provides the first large scale opportunity to gain meaningful insights into the concordance or discordance in micro- and macroscopic structure and function. The philosophy, strategy, algorithm development, data acquisition techniques and validation methods are described in this report along with database structures. Examples of results are described for the normal adult human brain as well as examples in patients with Alzheimer's disease and multiple sclerosis. The ability to quantify the variance of the human brain as a function of age in a large population of subjects for whom data is also available about their genetic composition and behaviour will allow for the first assessment of cerebral genotype-phenotype-behavioural correlations in humans to take place in a population this large. This approach and its application should provide new insights and opportunities for investigators interested in basic neuroscience, clinical diagnostics and the evaluation of neuropsychiatric disorders in patients.

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 Dates: 2001
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 511311
Other: P9398
DOI: 10.1098/rstb.2001.0915
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Title: Philosophical Transactions of the Royal Society of London - Series B, Biological Sciences
Source Genre: Journal
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Pages: - Volume / Issue: 356 Sequence Number: - Start / End Page: 1293 - 1322 Identifier: -