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  Age dependency of the hemodynamic response as measured by functional near-infrared spectroscopy

Schroeter, M. L., Zysset, S., Kruggel, F., & von Cramon, D. Y. (2003). Age dependency of the hemodynamic response as measured by functional near-infrared spectroscopy. NeuroImage, 19(3), 555-564. doi:10.1016/S1053-8119(03)00155-1.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-9B47-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-1F6C-A
Genre: Journal Article

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schroeter_agedependency.pdf (Publisher version), 400KB
 
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 Creators:
Schroeter, Matthias L.1, Author              
Zysset, Stefan1, Author              
Kruggel, F.1, 2, Author              
von Cramon, D. Yves1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              
2Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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Free keywords: Aging; Near-infrared spectroscopy; Stroop
 Abstract: Aging reduces cerebral blood flow in association cortices during rest. However, the influence of age on functional brain activation is still controversial. The aim of our study was to examine age dependency of brain activation in primary and association cortices. Therefore, changes in the concentration of oxy- and deoxyhemoglobin as well as changes in the redox state of cytochrome-c-oxidase (Cyt-Ox) were measured by functional near-infrared spectroscopy (fNIRS) in the lateral prefrontal and motor cortices during an event-related Stroop interference task. Fourteen young (23.9 ± 3.1 years old) and 14 elderly subjects (65.1 ± 3.1) participated in the study. Data revealed two effects of aging on brain activation: (1) Elderly and young subjects used the lateral prefrontal cortex to cope with interference during the Stroop task. In young subjects, the vascular response was higher during incongruent than neutral trials in the entire examined lateral prefrontal cortex. However, in the elderly, all lateral prefrontal regions showed a hemodynamic response but not necessarily a specific interference effect. (2) The hemodynamic response was reduced in elderly subjects in the lateral prefrontal association cortex, but obviously not in the motor cortex. We propose that calculating effect sizes is the only reliable approach to analyze age-related effects in fNIRS studies, because they are independent from the assumed differential pathlength factor. In summary, our findings suggest that aging decreases the hemodynamic response in the frontal association cortex during functional activation, omitting the primary motor cortex.

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Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
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 Identifiers: eDoc: 239162
Other: P6712
DOI: 10.1016/S1053-8119(03)00155-1
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 19 (3) Sequence Number: - Start / End Page: 555 - 564 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166