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  Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells

Schroeter, M. L., Müller, S., Lindenau, J., Wiesner, B., Hanisch, U. K., Wolf, G., et al. (2001). Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells. NeuroReport, 12(11), 2513-2517.

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 Creators:
Schroeter, Matthias L.1, Author           
Müller, S., Author
Lindenau, J., Author
Wiesner, B., Author
Hanisch, U. K., Author
Wolf, G., Author
Blasig, I. E., Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: Astrocytes; Blood-brain barrier; Brain capillary endothelial cells; Cytokines; Free radicals; Manganese superoxide dismutase; Reactive oxygen species
 Abstract: Astrocytes induce blood-brain barrier (BBB) properties in brain endothelial cells (EC)*O(2)*, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat EC was investigated in two coculture models of the BBB, allowing either exchange of soluble factors or additionally cellular contacts. Activity, protein content and mRNA expression of endothelial MnSOD were significantly increased in both coculture models in comparison to monoculture by soluble astrocytic factors, such as cytokines. High activity of endothelial MnSOD may be considered as a further essential property of the BBB, which is induced and maintained by astrocytes.

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Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 239692
ISI: 000170141600046
Other: P7070
 Degree: -

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Title: NeuroReport
Source Genre: Journal
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Affiliations:
Publ. Info: Oxford, UK : Rapid Communications of Oxford Ltd.
Pages: - Volume / Issue: 12 (11) Sequence Number: - Start / End Page: 2513 - 2517 Identifier: ISSN: 0959-4965
CoNE: https://pure.mpg.de/cone/journals/resource/954925578070