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  BASE imaging: A new spin labeling technique for measuring absolute perfusion changes

Schwarzbauer, C., & Heinke, W. (1998). BASE imaging: A new spin labeling technique for measuring absolute perfusion changes. Magnetic Resonance in Medicine, 39(5), 717-722. doi:10.1002/mrm.1910390508.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A012-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-F455-2
Genre: Journal Article

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 Creators:
Schwarzbauer, Christian1, Author              
Heinke, Wolfgang, Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634574              

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Free keywords: cerebral blood flow; perfusion; fMRI
 Abstract: A new technique for magnetic resonance imaging of absolute perfusion changes that uses magnetically labeled tissue water proton spins as a freely diffusible tracer is described. It consists of unprepared basis (BA) images that serve as a reference and selective (SE) inversion prepared images that are sensitive to perfusion changes. In the present study, the BASE technique was applied to functional neuroimaging. BA and SE images were alternatingly and repeatedly acquired during periods of visual stimulation and control. Visual stimulation was achieved with an alternating black/white checkerboard operating at a frequency of 8 Hz. Maps of the absolute cerebral blood flow changes (ACBF) were calculated from the image intensities of the corresponding BA and SE images. The individual mean values of ACBF measured in five healthy volunteers ranged from 69 ± 18 to 99 ± 26 ml/min/100 g. Since the BASE technique does not require nonselective spin inversion, it can be used with small transmit/receive head coils (e.g., surface coils). In addition, the BASE technique is robust against a mismatch of the inversion and detection slice profiles.

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Language(s): eng - English
 Dates: 1998
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239409
ISI: 000073234200007
Other: P6864
DOI: 10.1002/mrm.1910390508
 Degree: -

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 39 (5) Sequence Number: - Start / End Page: 717 - 722 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149