English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Cerebral haemoglobin oxygenation during sustained visual stimulation: A near–infrared spectroscopy study

Heekeren, H., Obrig, H., Wenzel, R., Eberle, K., Ruben, J., Villringer, K., et al. (1997). Cerebral haemoglobin oxygenation during sustained visual stimulation: A near–infrared spectroscopy study. Proceedings of the Royal Society of London Series B-Biological Sciences, 352(1354), 743-750. doi:10.1098/rstb.1997.0057.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A359-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-D4CF-6
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Heekeren, H., Author
Obrig, Hellmuth1, Author              
Wenzel, R., Author
Eberle, K., Author
Ruben, J., Author
Villringer, Kersten, Author
Kurth, R., Author
Villringer, Arno1, Author              
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Using near–infrared spectroscopy, we investigated the time–course of the concentrations of oxygenated haemoglobin, [oxy–Hb], and deoxygenated haemoglobin, [deoxy–Hb], in the occipital cortex of healthy human adults during sustained visual stimulation. Within a few seconds after stimulation (coloured dodecahedrons) we observed a decrease in [deoxy–Hb], peaking after 13 s (‘initial undershoot’). In the subsequent 1–2 min, in seven out of ten subjects, [deoxy–Hb] gradually returned to a plateau closer to the baseline level. After cessation of stimulation, there was a ‘post–stimulus overshoot’ in the concentration of deoxyhaemoglobin. There was a statistically significant correlation between the size of the ‘initial undershoot’ and the ‘post–stimulus overshoot’. The concentration of oxyhaemoglobin increased upon functional activation. However, in the mean across all subjects there was no initial overshoot. After approximately 19 s it reached a plateau and remained constantly elevated throughout the activation period. After cessation of activation there was a ‘post–stimulus undershoot’ of oxyhaemoglobin. It is important to consider the time–course of haemoglobin oxygenation when interpreting functional activation data, especially those data obtained with oxygenation–sensitive methods, such as BOLD contrast fMRI.

Details

show
hide
Language(s):
 Dates: 1997-06-291997-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 511519
Other: P9098
DOI: 10.1098/rstb.1997.0057
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the Royal Society of London Series B-Biological Sciences
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 352 (1354) Sequence Number: - Start / End Page: 743 - 750 Identifier: -