English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Changes of neural activity correlate with the severity of cortical ischemia in patients with unilateral major cerebral artery occlusion

Bundo, M., Inao, S., Nakamura, A., Kato, T., Ito, K., Tadokoro, M., et al. (2002). Changes of neural activity correlate with the severity of cortical ischemia in patients with unilateral major cerebral artery occlusion. Stroke, 33, 61-66.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A38D-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-4486-B
Genre: Journal Article

Files

show Files
hide Files
:
bundo.pdf (Any fulltext), 162KB
Name:
bundo.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: PUBLIC
License:
-

Locators

show

Creators

show
hide
 Creators:
Bundo, M., Author
Inao, S., Author
Nakamura, Akinori1, Author              
Kato, T., Author
Ito, Koji, Author
Tadokoro, M., Author
Kabeya, R., Author
Sugimoto, T., Author
Kajita, Y., Author
Yoshida, J., Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

Content

show
hide
Free keywords: Cerebral blood flow; Ischemia; Occlusion; Somatosensory evoked potentials
 Abstract: BACKGROUND AND PURPOSE: In major cerebral arterial steno-occlusive diseases, there can be remarkably decreased hemodynamic reserve without marked neurological impairments. In such settings, it is not known whether the neural activity is well maintained or disturbed according to the severity of cerebral ischemia. The present study was therefore undertaken to examine the neural activity under mild cerebral ischemia resulting from major cerebral arterial occlusion. METHODS: Seven patients with minor neurological impairment as well as either unilateral internal carotid artery or middle cerebral artery occlusion were studied. The severity of the cortical ischemia was assessed by measuring regional cerebral blood flow (rCBF) with positron emission tomography. The change in neural activity in the ischemic brain was then evaluated by means of somatosensory evoked magnetic field with magnetoencephalography. RESULTS: The rCBF in the primary sensory area and the strength of the initial component of somatosensory evoked magnetic field (N20 m) were significantly reduced (P<0.01) and the second component (P30 m) was significantly augmented (P<0.05) in the lesioned cerebral hemisphere as compared with the nonlesioned hemisphere. The asymmetry indexes for N20 m were positively correlated (r=0.78) and those for P30 m were inversely correlated (r=-0.92) with asymmetry indexes for rCBF. CONCLUSIONS: In patients with either unilateral internal carotid artery or middle cerebral artery occlusion and minor neural impairments, there was a reduction of afferent signal and an augmentation of the secondary response of the neurons in the primary sensory area. This showed correlation with the severity of cortical ischemia.

Details

show
hide
Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239229
Other: P6751
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Stroke
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Philadelphia, PA : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 33 Sequence Number: - Start / End Page: 61 - 66 Identifier: ISSN: 0039-2499
CoNE: /journals/resource/954925447729