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  Characterization of cerebral microangiopathy using 3 Tesla MRI: Correlation with neurological impairment and vascular risk factors

Hund-Georgiadis, M., Ballaschke, O., Scheid, R., Norris, D. G., & von Cramon, D. Y. (2002). Characterization of cerebral microangiopathy using 3 Tesla MRI: Correlation with neurological impairment and vascular risk factors. Journal of Magnetic Resonance Imaging, 15(1), 1-7. doi:10.1002/jmri.10039.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A3A4-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7CC1-6
Genre: Journal Article

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Hund-Georgiadis, Margret1, Author              
Ballaschke, Olaf2, Author              
Scheid, Rainer1, Author              
Norris, David G.1, Author              
von Cramon, D. Yves1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              
2External Organizations, ou_persistent22              

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 Abstract: To investigate whether clinical and neuropsychological impairment in cerebral small-vessel disease (CSVD) can be evaluated by means of morphological magnetic resonance imaging (MRI). Materials and Methods MRI at 3 Tesla in T2- and T1-weighted sequences was evaluated in 44 patients with cerebral microangiopathy, and 30 patients with combined cerebral micro- and macroangiopathy. The MR characteristics were correlated to clinical data, attentional impairment, and the patients' individual vascular risk factor profiles. Fifteen healthy age-matched control subjects participated in the study to assess MR signal changes in nonhypertensive elderly subjects. Results Patients and normal controls differed significantly in the extent of MR signal changes. A close relation between age, obesity, hypertension, and MR signal abnormalities was evident in all patients. Patients with pure CSVD additionally showed an association between their MR-defined severity of disease and their degree of neurological impairment, and their vascular risk score. In contrast, attentional impairment did not relate to the MR-defined severity of CSVD. Conclusion MR signal changes in CSVD show a close relationship to some risk factors of individual patients. J. Magn. Reson.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 239343
ISI: 000174759400001
Other: P6808
DOI: 10.1002/jmri.10039
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 15 (1) Sequence Number: - Start / End Page: 1 - 7 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512