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  Characterization of cerebral small vessel disease by proton spectroscopy and morphological magnetic resonance

Hund-Georgiadis, M., Norris, D. G., Guthke, T., & von Cramon, D. Y. (2001). Characterization of cerebral small vessel disease by proton spectroscopy and morphological magnetic resonance. Cerebrovascular Diseases, 12(2), 82-90. doi:10.1159/000047686.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A3A8-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7E01-4
Genre: Journal Article

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 Creators:
Hund-Georgiadis, Margret1, Author              
Norris, David G.1, Author              
Guthke, Thomas2, Author              
von Cramon, D. Yves1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              
2External Organizations, ou_persistent22              

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Free keywords: Cerebral small vessel disease; Proton spectroscopy; Cognitive impairment; Cholin; N-acetyl aspartate
 Abstract: This study sought to investigate whether clinical and neuropsychological impairment in cerebral small vessel disease (CSVD) can be evaluated by proton spectroscopy (1H-MRS) and structural magnetic resonance (MR) imaging. Sixteen patients with CSVD and 15 healthy age-matched controls participated in the study. In addition to spectroscopic and structural MR examination all patients underwent a comprehensive clinical and neuropsychological investigation. Significant differences in between patients and controls were revealed by 1H-MRS in the parietal white matter: decreased metabolic ratios of N-acetyl aspartate to choline (NAA/Cho; patients: 1.37 ± 0.17, control: 1.72 ± 0.25, p < 0.001) and of N-acetyl aspartate to creatin (NAA/Cr; patients: 1.41 ± 0.15, control: 1.66 ± 0.2, p < 0.01) indicated a pathological state. Evaluation of spectroscopic and neuropsychological data revealed a close relation between attentional impairment, i.e. delayed cerebral transmission time and decreased NAA/Cho and NAA/Cr (r = 0.62, p = 0.014). In sum, 1H-MRS allowed a clear discrimination between patients with CSVD and age-matched normal controls. Moreover, comparisons of 1H-MRS and neuropsychological data suggested that NAA metabolic levels, and particularly the delay in cerebral transmission time, could be potential predictors of the severeness of attentional impairment.

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Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239664
ISI: 000170526900002
Other: P7048
DOI: 10.1159/000047686
 Degree: -

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Title: Cerebrovascular Diseases
  Other : Cerebrovasc. Dis.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel : Karger
Pages: - Volume / Issue: 12 (2) Sequence Number: - Start / End Page: 82 - 90 Identifier: ISSN: 1015-9770
CoNE: https://pure.mpg.de/cone/journals/resource/954925585262