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  Characterization of CBF response to somatosensory stimulation: Model and influence of anesthetics

Lindauer, U., Villringer, A., & Dirnagl, U. (1993). Characterization of CBF response to somatosensory stimulation: Model and influence of anesthetics. American Journal of Physiology, 264(4), H1223-1228. doi:10.1152/ajpheart.1993.264.4.H1223.

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 Creators:
Lindauer, U.1, Author
Villringer, Arno1, Author              
Dirnagl, U.1, Author
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1External Organizations, ou_persistent22              

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 Abstract: We investigated the cerebral blood flow (CBF) response to somatosensory stimulation. Stimulation of neuronal activity was performed by deflection (2-3/s) of the mystacial vibrissae in rats over a period of 60 s, and regional cortical CBF was measured continuously in the contralateral somatosensory cortex with laser-Doppler flowmetry. CBF within the somatosensory cortex was studied through the parietal bone thinned to translucency (n = 7) or through a closed cranial window with the dura mater removed (n = 7). In addition, the differential effect of anesthetics (halothane-N2O, n = 5; thiobutabarbiturate, n = 5; and alpha-chloralose, n = 7) on the CBF response to stimulation was investigated. After a rapid increase after stimulation onset (maximum reached within 2-3 s), CBF remained above baseline with a slight tendency to decrease despite continued stimulation. On termination of stimulation, CBF fell to near prestimulation values within 2-3 s. The following mean CBF responses above baseline during the 60-s stimulation period were obtained: halothane-N2O anesthesia, 25.4 +/- 5.9%; thiobutabarbiturate anesthesia, 10.6 +/- 2.4%; and alpha-chloralose anesthesia, 16.9 +/- 2.3 (through the translucent bone) and 16.2 +/- 2.9% (closed cranial window, dura removed). We conclude that coupling of CBF to neuronal function has a very high temporal resolution (< 3 s) and that whisker deflection in rats provides a physiological stimulus to study coupling with laser-Doppler flowmetry.

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Language(s): eng - English
 Dates: 1993
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 510886
Other: P9154
DOI: 10.1152/ajpheart.1993.264.4.H1223
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Title: American Journal of Physiology
Source Genre: Journal
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Pages: - Volume / Issue: 264 (4) Sequence Number: - Start / End Page: H1223 - 1228 Identifier: -