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  Continuous arterial spin labeling at the human common carotid artery: The influence of transit times

Mildner, T., Möller, H. E., Driesel, W., Norris, D. G., & Trampel, R. (2005). Continuous arterial spin labeling at the human common carotid artery: The influence of transit times. NMR in Biomedicine, 18(1), 19-23. doi:10.1002/nbm.917.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-A5F9-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-EBAE-0
Genre: Journal Article

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 Creators:
Mildner, Toralf1, Author              
Möller, Harald E.1, Author              
Driesel, Wolfgang1, Author              
Norris, David G.2, Author              
Trampel, Robert1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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Free keywords: arterial spin labeling; cerebral blood flow; transit time; quantification; surface coil
 Abstract: In evaluating the sensitivity of arterial spin labeling (CASL) and for quantification of perfusion, knowledge of the transit time from the labeling plane to the imaging slice is crucial. The purpose of the current study was to obtain estimates of transit times relevant under the specific experimental conditions of CASL in human subjects using a separate local labeling coil at the neck. Specifically, the post-label delay (PLD), i.e. the time between the end of the labeling period and the image acquisition, was varied either with or without additional application of crusher gradients to suppress intravascular signal contributions. The overall sensitivity change for varying the PLD between 1000 and 1700 ms was low. A tissue transit time from the neck to an axial supraventricular section through Broca's knee was obtained by fitting the PLD dependence to a two-compartment model. Averaging over subjects yielded 1930 ± 110 ms for the tissue transit time, and 73 ± 5 ml min−1 100 g−1 for the cerebral blood flow. Small areas that exhibited a very high signal change upon labeling were indicative of regional variation in cerebral blood flow related to vascular anatomy. Copyright © 2004 John Wiley & Sons, Ltd.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239604
DOI: 10.1002/nbm.917
Other: P6997
 Degree: -

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Title: NMR in Biomedicine
Source Genre: Journal
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Publ. Info: London : Heyden & Son
Pages: - Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 19 - 23 Identifier: ISSN: 0952-3480
CoNE: https://pure.mpg.de/cone/journals/resource/954925574973