English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Differentiation of cerebral tumors using multi-section echo planar MR perfusion imaging

Preul, C., Kühn, B., Lang, E. W., Mehdorn, H. M., Heller, M., & Link, J. (2003). Differentiation of cerebral tumors using multi-section echo planar MR perfusion imaging. European Journal of Radiology, 48(3), 244-251. doi:10.1016/S0720-048X(03)00050-0.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-ABAC-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-30F4-0
Genre: Journal Article

Files

show Files
hide Files
:
preul.pdf (Any fulltext), 540KB
Name:
preul.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Preul, Christoph1, Author              
Kühn, B., Author
Lang, E. W., Author
Mehdorn, H. M., Author
Heller, M., Author
Link, J., Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

Content

show
hide
Free keywords: Malignant glioma; Perfusion measurement; Echo planar imaging; Cerebral blood volume
 Abstract: Objective: We have investigated the performance of magnetic resonance (MR) perfusion imaging to differentiate between astrocytomas grade II, grade III and glioblastomas in a prospective study. Materials and methods: In 33 patients with suspected supratentorial primary cerebral tumors we performed multi-section Echo Planar MR perfusion imaging. Regional cerebral blood volume (rCBV) maps were calculated and the maximum rCBV was determined from the entire lesion. This value was divided by the mean rCBV value from the contralateral side, which provided the rCBV index used in this study. The rCBV index was correlated with the histological tumor classification after stereotactic biopsy (n=7) or open resection (n=26). Results: The maximum rCBV index was 1.2±0.8 for grade II astrocytomas (n=3), 4.0±1.2 for grade III astrocytomas (n=13), and 10.3±3.3 for glioblastomas (n=17). The difference between grade III astrocytomas and glioblastomas was highly significant (P<0.001). Discussion and conclusion: The rCBV index measured with multi-section Echo Planar MR perfusion is capable of differentiating grade III astrocytomas from glioblastomas. It serves as an additional parameter to establish a diagnosis in cases where it is not possible to clearly differentiate between these types of tumors on the basis of conventional MR imaging. MR perfusion imaging also provides information about spatial heterogeneities within a tumor which might improve diagnostic performance. This technology may also be of interest for follow-up examinations after histological diagnosis and further treatment.

Details

show
hide
Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239275
Other: P6775
DOI: 10.1016/S0720-048X(03)00050-0
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Radiology
  Other : Eur. J. Radiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Stuttgart : Elsevier
Pages: - Volume / Issue: 48 (3) Sequence Number: - Start / End Page: 244 - 251 Identifier: ISSN: 0720-048X
CoNE: https://pure.mpg.de/cone/journals/resource/954925532999