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  Diffuse axonal injury associated with chronic traumatic brain injury: Evidence from T2*-weighted gradient-echo imaging at 3 T

Scheid, R., Preul, C., Gruber, O., Wiggins, C. J., & von Cramon, D. Y. (2003). Diffuse axonal injury associated with chronic traumatic brain injury: Evidence from T2*-weighted gradient-echo imaging at 3 T. American Journal of Neuroradiology, 24(6), 1049-1056.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-ABC4-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-2784-8
Genre: Journal Article

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scheid_diffuseaxonal.pdf (Publisher version), 308KB
 
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 Creators:
Scheid, Rainer1, Author              
Preul, Christoph1, Author              
Gruber, Oliver1, Author              
Wiggins, Christopher J.1, Author              
von Cramon, D. Yves1, Author              
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1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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 Abstract: BACKGROUND AND PURPOSE: Diffuse axonal injury is frequently accompanied by tissue tear hemorrhages. We examined whether high field strength T2*-weighted gradient-echo imaging performed during the chronic stage of traumatic brain injury may have advantages in the evaluation of diffuse axonal injury as compared with T1- and T2-weighted MR imaging. METHODS: Prospective MR imaging of 66 patients (age range, 17-57 years) was performed using a 3-T system 3 to 292 months (median, 23.5 months) after traumatic brain injury. T1-, T2-, T2*-hypointense and T2-hyperintense foci of 1- to 15-mm diameter were registered in 10 brain regions by two readers separately. Foci that appeared hypointense both on the T1- and T2- and/or on the T2*-weighted images were defined as traumatic microbleeds. RESULTS: For 46 (69.7%) of the patients, T2*-weighted gradient-echo imaging revealed traumatic microbleeds. Hyperintense foci were observed on the T2-weighted images of only 15 (22.7%) patients. T2*-weighted imaging showed significantly more traumatic microbleeds (P =.000) than did T1- and T2-weighted imaging. Interobserver agreement was strong (kappa = 0.79, tau = 0.749, P =.000). For 14 (21.2%) of the patients, T2*-weighted gradient-echo imaging revealed traumatic microbleeds in the corpus callosum, whereas for only two (3%), hyperintense callosal lesions were seen on the T2-weighted images. Although a significant correlation existed between the total amount and callosal appearance of traumatic microbleeds and Glasgow Coma Scale scores (P =.000), no correlation existed with extended Glasgow Outcome Scale scores. CONCLUSION: T2*-weighted gradient-echo imaging at high field strength is a useful tool for the evaluation of diffuse axonal injury during the chronic stage of traumatic brain injury. Diffuse axonal injury-related brain lesions are mainly hemorrhagic. The relevance of diffuse axonal injury for long-term clinical outcome is uncertain.

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Language(s): eng - English
 Dates: 2003
 Publication Status: Published in print
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 Identifiers: eDoc: 239724
Other: P7092
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Title: American Journal of Neuroradiology
Source Genre: Journal
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Publ. Info: Baltimore : Williams & Wilkins Co.
Pages: - Volume / Issue: 24 (6) Sequence Number: - Start / End Page: 1049 - 1056 Identifier: ISSN: 0195-6108
CoNE: https://pure.mpg.de/cone/journals/resource/954925490872