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  Directed forgetting in schizophrenia Prefrontal memory and inhibition deficits

Müller, U., Ullsperger, M., Hammerstein, E., Sachweh, S., & Becker, T. (2005). Directed forgetting in schizophrenia Prefrontal memory and inhibition deficits. European Archives of Psychiatry and Clinical Neuroscience, 255(4), 251-257. doi:10.1007/s00406-004-0554-6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-AC06-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-32E5-2
Genre: Journal Article

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 Creators:
Müller, Ulrich1, Author              
Ullsperger, Markus2, Author              
Hammerstein, Eva, Author
Sachweh, Stefan, Author
Becker, Thomas, Author
Affiliations:
1External Organizations, ou_persistent22              
2Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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Free keywords: Directed forgetting; Inhibition; Memory; Prefrontal; Schizophrenia
 Abstract: Schizophrenia is associated with cognitive deficits in the domains of working memory, strategic memory and other executive functions. In the current study we used a computerised and item–cued variant of the directed forgetting (DF) task to assess inhibitory processes in verbal memory. Twenty–five patients with schizophrenia and a group of matched controls were tested. Recognition memory was better for to–be–remembered (TBR) than for to–be–forgotten (TBF) words in both patients and controls. As compared to healthy controls the patients with schizophrenia showed overall memory deficits and difficulties to inhibit memories as indicated by a significant group by cue interaction and a smaller DF effect. The DF effect was associated with disease duration but not with symptom severity. Memoryrelated inhibition problems are difficult to assess in patients with schizophrenia and might be related to fronto–temporal disconnection.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 238147
Other: P6525
DOI: 10.1007/s00406-004-0554-6
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Title: European Archives of Psychiatry and Clinical Neuroscience
Source Genre: Journal
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Publ. Info: Berlin : Springer International
Pages: - Volume / Issue: 255 (4) Sequence Number: - Start / End Page: 251 - 257 Identifier: ISSN: 0940-1334
CoNE: https://pure.mpg.de/cone/journals/resource/954927622119