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  Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency.

Moore, J. W., Ruge, D., Wenke, D., Rothwell, J. C., & Haggard, P. (2010). Disrupting the experience of control in the human brain: pre-supplementary motor area contributes to the sense of agency. Proceedings of the Royal Society of London Series B-Biological Sciences, 277(1693), 2503-2509. doi:10.1098/rspb.2010.0404.

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 Creators:
Moore, James W.1, Author
Ruge, Diane2, Author
Wenke, Dorit3, 4, Author           
Rothwell, John C.2, Author
Haggard, Patrick1, Author
Affiliations:
1Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
2Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
3Department Psychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634564              
4Department of Experimental, Clinical and Health Psychology, Ghent University, Ghent, Belgium, ou_persistent22              

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Free keywords: Agency; Pre-supplementary motor area; Sensorimotor cortex; Theta-burst stimulation; Transcranial magnetic stimulation; Voluntary action
 Abstract: The feeling of controlling events through one's actions is fundamental to human experience, but its neural basis remains unclear. This 'sense of agency' (SoA) can be measured quantitatively as a temporal linkage between voluntary actions and their external effects. We investigated the brain areas underlying this aspect of action awareness by using theta-burst stimulation to locally and reversibly disrupt human brain function. Disruption of the pre-supplementary motor area (pre-SMA), a key structure for preparation and initiation of a voluntary action, was shown to reduce the temporal linkage between a voluntary key-press action and a subsequent electrocutaneous stimulus. In contrast, disruption of the sensorimotor cortex, which processes signals more directly related to action execution and sensory feedback, had no significant effect. Our results provide the first direct evidence of a pre-SMA contribution to SoA. © 2010 The Royal Society

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Language(s): eng - English
 Dates: 2010-02-262010-03-192010-04-072010-08-22
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 512135
DOI: 10.1098/rspb.2010.0404
Other: P11540
PMC: PMC2894930
PMID: 20375048
 Degree: -

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Funding program : Research Fellowship
Funding organization : Royal Society University
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Funding program : Major Research Fellowship
Funding organization : Leverhulme Trust
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Funding organization : Dystonia Medical Research Foundation (DMRF)
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Funding organization : Action Medical Research
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Funding organization : Wellington Hospital
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Funding program : -
Funding organization : Medical Research Council (MRC)
Project name : Intentional Inhibition of Human Action
Grant ID : ES/H006419/1
Funding program : -
Funding organization : Economic & Social Research Council (ESRC)
Project name : Being in control: the psychology of agency
Grant ID : RES-000-23-1571
Funding program : -
Funding organization : Economic & Social Research Council (ESRC)

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Title: Proceedings of the Royal Society of London Series B-Biological Sciences
Source Genre: Journal
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Publ. Info: London : Printed for the Royal Society and sold by Harrison & Sons
Pages: - Volume / Issue: 277 (1693) Sequence Number: - Start / End Page: 2503 - 2509 Identifier: ISSN: 0962-8452
CoNE: https://pure.mpg.de/cone/journals/resource/110975500577295_2