Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia

Gallinat, J., Mulert, C., Bajbouj, M., Herrmann, W. M., Schunter, J., Senkowski, D., et al. (2002). Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia. NeuroImage, 17(1), 110-127. doi:10.1006/nimg.2002.1213.

Item is

Dateien

einblenden: Dateien
ausblenden: Dateien
:
16977.pdf (beliebiger Volltext), 573KB
Name:
16977.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Gallinat, J., Autor
Mulert, C., Autor
Bajbouj, M., Autor
Herrmann, W. M., Autor
Schunter, J., Autor
Senkowski, Daniel1, Autor           
Moukhtieva, R., Autor
Kronfeldt, D., Autor
Winterer, G., Autor
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Schizophrenia; Attention deficit; Anterior cingulate cortex; Auditory cortex; Event-related potentials; Minimum-norm analysis; LORETA; Multiple dipole analysis; BESA
 Zusammenfassung: Attentiondeficits have been consistently described in schizophrenia. Functional neuroimaging and electrophysiological studies have focused on anterior cingulate cortex (ACC) dysfunction as a possible mediator. However, recent basic research has suggested that the effect of attention is also observed as a relative amplification of activity in modality-associated cortical areas. In the present study, the question was addressed whether an amplification deficit is seen in the auditory cortex of schizophrenic patients during an attention-requiring choice reaction task. Twenty-one drug-free schizophrenic patients and 21 age- and sex-matched healthy controls were studied (32-channel EEG). The underlying generators of the event-related N1 component were separated in neuroanatomic space using a minimum-norm (LORETA) and a multiple dipole (BESA) approach. Both methods revealed activation in the primary auditory cortex (peak latency ≈ 100 ms) and in the area of the ACC (peak latency ≈ 130 ms). In addition, the adapted multiple dipole model also showed a temporal-radial source activation in nonprimary auditory areas (peak latency ≈ 140 ms). In schizophrenic patients, significant activation deficits were found in the ACC as well as in the left nonprimary auditory areas that differentially correlated with negative and positive symptoms. The results suggest that (1) the source in the nonprimary auditory cortex is detected only with a multiple dipole approach and (2) that the N1 generators in the ACC and in the nonprimary auditory cortex are dysfunctional in schizophrenia. This would be in line with the notion that attention deficits in schizophrenia involve an extended cortical network.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2002
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 239262
ISI: 000178102000008
Anderer: P6765
DOI: 10.1006/nimg.2002.1213
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: NeuroImage
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 17 (1) Artikelnummer: - Start- / Endseite: 110 - 127 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166