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  Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly

Wolf, H., Grunwald, M., Kruggel, F., Riedel-Heller, S. G., Angerhöfer, S., Hojjatoleslami, S. A., et al. (2001). Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of Aging, 22(2), 177-186. doi:10.1016/S0197-4580(00)00238-4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-B9C4-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-29EA-1
Genre: Journal Article

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 Creators:
Wolf, H., Author
Grunwald, M., Author
Kruggel, F.1, 2, Author              
Riedel-Heller, S. G., Author
Angerhöfer, S., Author
Hojjatoleslami, S. A.2, Author              
Hensel, A., Author
Arendt, T., Author
Gertz, H. J., Author
Affiliations:
1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
2MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: Hippocampus; MRI; Volumetry; Aging; Cognition; Mild cognitive impairment; Mild dementia; Alzheimer’s disease; Asymmetry; Laterality; Clinical dementia rating; Population-based
 Abstract: The sensitivity of MRI volumetric measures to detect cognitive dysfunction is examined in 39 participants of an epidemiological field study (age 75–85, MMSE 19–30). According to Clinical dementia rating (CDR), 17 subjects had normal cognition (CDR 0), 12 had questionable (CDR 0.5) and 10 mild dementia (CDR 1). Discriminant analysis based on four hippocampal measures resulted in a correct classification of 76.9% of all subjects. Left-sided and posterior hippocampal measures were more responsible for group discrimination than right-sided and anterior measures. In CDR 0.5, a significant hippocampal volume reduction of 14.3% vs.11.3% (left vs. right) relative to normal was found. The right hippocampus was significantly greater than the left in CDR 0 and CDR 0.5, but not in CDR 1. The magnitude of non-directional hippocampal asymmetry increased with decreasing cognitive state. We conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for Alzheimer’s disease in the elderly population.

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Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239668
ISI: 000167154800002
Other: P7052
DOI: 10.1016/S0197-4580(00)00238-4
 Degree: -

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Title: Neurobiology of Aging
  Other : Neurobiol. Aging
Source Genre: Journal
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Affiliations:
Publ. Info: New York, NY [etc.] : Elsevier
Pages: - Volume / Issue: 22 (2) Sequence Number: - Start / End Page: 177 - 186 Identifier: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902