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  Influence of anisotropic conductivity of the white matter tissue on EEG source reconstruction a FEM simulation study

Güllmar, D., Reichenbach, J. R., Anwander, A., Knösche, T. R., Wolters, C. H., Eiselt, M., et al. (2005). Influence of anisotropic conductivity of the white matter tissue on EEG source reconstruction a FEM simulation study. International Journal of Bioelectromagnetism, 7(1), 108-110.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-BCF4-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-113A-C
Genre: Journal Article

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 Creators:
Güllmar, Daniel, Author
Reichenbach, Jürgen R., Author
Anwander, Alfred1, Author              
Knösche, Thomas R.2, Author              
Wolters, Carsten Hermann2, Author              
Eiselt, Michael, Author
Haueisen, Jens, Author
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Methods and Development Unit MEG and EEG: Signal Analysis and Modelling, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634559              

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Free keywords: Anisotropy; Conductivity; FEM; Animal model; Simulation; EEG
 Abstract: The aim of this study was to quantify the influence of the inclusion of anisotropic conductivity on EEG source reconstruction. We applied high-resolution finite element modeling and performed forward and inverse simulation with over 4000 single dipoles placed around an anisotropic volume block (with an anisotropic ratio of 1:10) in a rabbit brain. We investigated three different orientation of the dipoles with respect to the anisotropy in the white matter block. We found a weak influence of the anisotropy in the forward simulation on the electric potential. The relative difference measure (RDM) between the potentials simulated with and without taking into account anisotropy was less than 0.009. The changes in magnitude (MAG) ranged from 0.944 to 1.036. Using the potentials of the forward simulation derived with the anisotropic model and performing source reconstruction by employing the isotropic model led to dipole shifts of up to 2 mm, however the mean shift over all dipoles and orientations of 0.05 mm was smaller than the grid size of the FEM model (0.6 mm). However, we found the source strength estimation to be more influenced by the anisotropy (up to 7-times magnified dipole strength).

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: eDoc: 263324
Other: P7154
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Title: International Journal of Bioelectromagnetism
Source Genre: Journal
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Pages: - Volume / Issue: 7 (1) Sequence Number: - Start / End Page: 108 - 110 Identifier: -