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  Influence of local and remote white matter conductivity anisotropy for a thalamic source on EEG/MEG field and return current computation

Wolters, C. H., Anwander, A., Tricoche, X., Lew, S., & Johnson, C. R. (2005). Influence of local and remote white matter conductivity anisotropy for a thalamic source on EEG/MEG field and return current computation. International Journal of Bioelectromagnetism, 7(1), 203-206.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-BD0B-E Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-113B-A
Genre: Journal Article

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 Creators:
Wolters, Carsten Hermann1, Author              
Anwander, Alfred2, Author              
Tricoche, X., Author
Lew, S., Author
Johnson, Christopher R., Author
Affiliations:
1Methods and Development Unit MEG and EEG: Signal Analysis and Modelling, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634559              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Anisotropy; EEG/MEG source reconstruction; Finite element method; Local conductivity changes; Return currents; Thalamus; Visualization
 Abstract: nverse methods are used to reconstruct current sources in the human brain by means of Electroencephalogra- phy (EEG) and Magnetoencephalography (MEG) measure- ments of event related fields or epileptic seizures. There exists a persistent uncertainty regarding the influence of anisotropy of the white matter compartment on neural source reconstruc- tion. In this paper, we study the sensitivity to anisotropy of the EEG/MEG forward problem for a thalamic source in a high resolution finite element volume conductor. The influence of anisotropy on computed fields will be presented by both high resolution visualization of fields and return current flow and topography and magnitude error measures. We pay particular attention to the influence of local conductivity changes in the neighborhood of the source. The combination of simulation and visualization provides deep insight into the effect of white matter conductivity anisotropy. We found that for both EEG and MEG formulations, the local presence of electrical anisotropy in the tissue surroun- ding the source substantially compromised the forward field computation, and correspondingly, the inverse source recons- truction. The degree of error resulting from the uncompen- sated presence of tissue anisotropy depended strongly on the proximity of the anisotropy to the source; remote anisotropy had a much weaker influence than anisotropic tissue that included the source.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
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 Identifiers: eDoc: 268099
Other: P7177
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Title: International Journal of Bioelectromagnetism
Source Genre: Journal
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Pages: - Volume / Issue: 7 (1) Sequence Number: - Start / End Page: 203 - 206 Identifier: -