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  Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model: A simulation and visualization study using high-resolution finite element modeling

Wolters, C. H., Anwander, A., Tricoche, X., Weinstein, D., Koch, M. A., & MacLeod, R. S. (2006). Influence of tissue conductivity anisotropy on EEG/MEG field and return current computation in a realistic head model: A simulation and visualization study using high-resolution finite element modeling. NeuroImage, 30(3), 813-826. doi:10.1016/j.neuroimage.2005.10.014.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-BD20-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002B-DE63-E
Genre: Journal Article

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 Creators:
Wolters, Carsten Hermann1, Author              
Anwander, Alfred2, 3, Author              
Tricoche, X., Author
Weinstein, D., Author
Koch, Martin A.1, Author              
MacLeod, R. S., Author
Affiliations:
1External Organizations, ou_persistent22              
2Methods and Development Unit Cortical Networks and Cognitive Functions, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634557              
3Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: EEG; MEG; Source reconstruction; Tissue conductivity anisotropy; CSF; Forward problem; Finite element method; Return current; Visualization
 Abstract: To achieve a deeper understanding of the brain, scientists, and clinicians use electroencephalography (EEG) and magnetoencephalography (MEG) inverse methods to reconstruct sources in the cortical sheet of the human brain. The influence of structural and electrical anisotropy in both the skull and the white matter on the EEG and MEG source reconstruction is not well understood. In this paper, we report on a study of the sensitivity to tissue anisotropy of the EEG/MEG forward problem for deep and superficial neocortical sources with differing orientation components in an anatomically accurate model of the human head. The goal of the study was to gain insight into the effect of anisotropy of skull and white matter conductivity through the visualization of field distributions, isopotential surfaces, and return current flow and through statistical error measures. One implicit premise of the study is that factors that affect the accuracy of the forward solution will have at least as strong an influence over solutions to the associated inverse problem. Major findings of the study include (1) anisotropic white matter conductivity causes return currents to flow in directions parallel to the white matter fiber tracts; (2) skull anisotropy has a smearing effect on the forward potential computation; and (3) the deeper a source lies and the more it is surrounded by anisotropic tissue, the larger the influence of this anisotropy on the resulting electric and magnetic fields. Therefore, for the EEG, the presence of tissue anisotropy both for the skull and white matter compartment substantially compromises the forward potential computation and as a consequence, the inverse source reconstruction. In contrast, for the MEG, only the anisotropy of the white matter compartment has a significant effect. Finally, return currents with high amplitudes were found in the highly conducting cerebrospinal fluid compartment, underscoring the need for accurate modeling of this space.

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Language(s): eng - English
 Dates: 2005-10-052005-12-202006
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 285678
Other: P7209
DOI: 10.1016/j.neuroimage.2005.10.014
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 30 (3) Sequence Number: - Start / End Page: 813 - 826 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166