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  Investigating the post-stimulus undershoot of the BOLD signal: A simultaneous fMRI and fNIRS study

Schroeter, M. L., Kupka, T., Mildner, T., Uludag, K., & von Cramon, D. Y. (2006). Investigating the post-stimulus undershoot of the BOLD signal: A simultaneous fMRI and fNIRS study. NeuroImage, 30(2), 349-358. doi:10.1016/j.neuroimage.2005.09.048.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-BF8F-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-392B-E
Genre: Journal Article

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 Creators:
Schroeter, Matthias L.1, Author              
Kupka, Thomas1, Author              
Mildner, Toralf2, Author              
Uludag, Kamil3, Author
von Cramon, D. Yves1, Author              
Affiliations:
1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3External Organizations, ou_persistent22              

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Free keywords: BOLD signal; Near-infrared spectroscopy; Post-stimulus undershoot
 Abstract: Measuring the hemodynamic response with functional magnetic resonance imaging (fMRI) together with functional near-infrared spectroscopy (fNIRS) may overcome limitations of single-method approaches. Accordingly, we measured the event-related hemodynamic response with both imaging methods simultaneously in young subjects during visual stimulation. An intertrial interval of 60 s was chosen to include the prolonged post-stimulus undershoot of the blood oxygenation level dependent (BOLD) signal. During visual stimulation, the BOLD signal, oxy-, and total hemoglobin (Hb) increased, whereas deoxy-Hb decreased. The post-stimulus period was characterized by an undershoot of the BOLD signal, oxy-Hb, and an overshoot of deoxy-Hb. Total Hb as measured by fNIRS returned to baseline immediately after the end of stimulation. Results suggest that the post-stimulus events as measured by fNIRS are dominated by a prolonged high-level oxygen consumption in the microvasculature. The contribution of a delayed return of blood volume to the BOLD post-stimulus undershoot in post-capillary veins as suggested by the Balloon and Windkessel models remains ambiguous. Temporal changes in the BOLD signal were highly correlated with deoxy-Hb, with lower correlation values for oxy- and total Hb. Furthermore, data show that fNIRS covers the outer 1 cm of the brain cortex. These results were confirmed by simultaneous fMRI/fNIRS measurements during rest. In conclusion, multimodal imaging approaches may contribute to the understanding of neurovascular coupling.

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Language(s): eng - English
 Dates: 2005-08-262005-06-142005-09-192005-10-272006-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 285262
Other: Epub 2005
DOI: 10.1016/j.neuroimage.2005.09.048
PMID: 16257236
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 30 (2) Sequence Number: - Start / End Page: 349 - 358 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166