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  In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease

Murai, T., Müller, U., Werheid, K., Sorger, D., Reuter, M., Becker, T., et al. (2001). In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease. Journal of Neuropsychiatry and Clinical Neurosciences, 13(2), 222-228. doi:10.1176/jnp.13.2.222.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-BFCC-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-29D6-D
Genre: Journal Article

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 Creators:
Murai, Toshia1, Author              
Müller, Ulrich1, Author              
Werheid, K.1, Author              
Sorger, D., Author
Reuter, Martin, Author
Becker, Thomas, Author
von Cramon, D. Yves1, Author              
Barthel, H., Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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 Abstract: Parkinson's disease affects various neurotransmitter systems. Using SPECT, the authors measured [(123)I]beta-CIT binding ratios of the caudate, putamen, medial thalamus, and dorsal midbrain over cerebellum in 16 patients with Parkinson's disease, and examined correlations with clinical ratings. Whereas striatal binding ratios (reflecting regional dopamine transporter densities) were associated with motor symptoms, dorsal midbrain binding ratios (reflecting regional serotonin transporter densities) were significantly correlated with the mentation, behavior, and mood subscale of the Unified Parkinson's Disease Rating Scale. These findings indicate that degeneration of the nigrostriatal dopaminergic neurons and a dysfunctional serotonergic raphe system contribute differentially to motor deficits and neuropsychiatric symptoms in Parkinson's disease.

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Language(s): eng - English
 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 238982
ISI: 000168687800008
Other: P6543
DOI: 10.1176/jnp.13.2.222
 Degree: -

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Title: Journal of Neuropsychiatry and Clinical Neurosciences
  Other : J. Neuropsychiatr. Clin. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : American Psychiatric Press
Pages: - Volume / Issue: 13 (2) Sequence Number: - Start / End Page: 222 - 228 Identifier: ISSN: 0895-0172
CoNE: https://pure.mpg.de/cone/journals/resource/954925559534