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  Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres

Gee, D. G., Biswal, B. B., Kelly, C., Stark, D. E., Margulies, D. S., Shehzad, Z. E., et al. (2011). Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres. NeuroImage, 54(1), 517-527. doi:10.1016/j.neuroimage.2010.05.073.

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 Creators:
Gee, Dylan G.1, Author
Biswal, Bharat B.2, 3, Author
Kelly, Clare1, Author
Stark, David E.4, Author
Margulies, Daniel S.5, Author              
Shehzad, Zarrar E.1, Author
Uddin, Lucina Q.6, Author
Klein, Donald F.1, 2, Author
Banich, Marie T.7, Author
Castellanos, F. Xavier1, 2, Author
Milham, Michael P.1, 2, Author
Affiliations:
1Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, New York University Child Study Center, NY, USA, ou_persistent22              
2Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA, ou_persistent22              
3Department of Radiology, University of Medicine and Dentistry, Newark, NJ, USA, ou_persistent22              
4Harvard Medical School, Boston, MA, USA, ou_persistent22              
5Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
6Department of Psychiatry, Stanford University, CA, USA, ou_persistent22              
7Department of Psychology, University of Colorado Boulder, CO, USA, ou_persistent22              

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 Abstract: Resting-state functional magnetic resonance imaging (fMRI) has provided a novel approach for examining interhemispheric interaction, demonstrating a high degree of functional connectivity between homotopic regions in opposite hemispheres. However, heterotopic resting-state functional connectivity (RSFC) remains relatively uncharacterized. In the present study, we examine non-homotopic regions, characterizing heterotopic RSFC and comparing it to intrahemispheric RSFC, to examine the impact of hemispheric separation on the integration and segregation of processing in the brain. Resting-state fMRI scans were acquired from 59 healthy participants to examine inter-regional correlations in spontaneous low frequency fluctuations in BOLD signal. Using a probabilistic atlas, we correlated probability-weighted time series from 112 regions (56 per hemisphere) distributed throughout the entire cerebrum. We compared RSFC for pairings of non-homologous regions located in different hemispheres (heterotopic connectivity) to RSFC for the same pairings when located within hemisphere (intrahemispheric connectivity). For positive connections, connectivity strength was greater within each hemisphere, consistent with integrated intrahemispheric processing. However, for negative connections, RSFC strength was greater between the hemispheres, consistent with segregated interhemispheric processing. These patterns were particularly notable for connections involving frontal and heteromodal regions. The distribution of positive and negative connectivity was nearly identical within and between the hemispheres, though we demonstrated detailed regional variation in distribution. We discuss implications for leading models of interhemispheric interaction. The future application of our analyses may provide important insight into impaired interhemispheric processing in clinical and aging populations.

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Language(s): eng - English
 Dates: 2010-06-042011-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 512095
Other: P11623
DOI: 10.1016/j.neuroimage.2010.05.073
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 54 (1) Sequence Number: - Start / End Page: 517 - 527 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166