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  Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacity

Bublak, P., Müller, U., Grön, G., Reuter, M., & von Cramon, D. Y. (2002). Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacity. Neuropsychology, 16(4), 577-590. doi:10.1037/0894-4105.16.4.577.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-C51B-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5C05-A
Genre: Journal Article

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Bublak, Peter1, Author              
Müller, Ulrich1, Author              
Grön, G., Author
Reuter, Martin, Author
von Cramon, D. Yves1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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 Abstract: It has been suggested that in patients with Parkinson's disease (PD), difficulties in the manipulation of information, which result in problems in executive tasks, are related to a reduction of working memory capacity (J. D. E. Gabrieli, J. Singh, G. T. Stebbins, & C. G. Goetz, 1996). The present study selectively varied the manipulation demand irrespective of the maintenance requirement. In a group of 14 PD patients, performance declined overproportionally with the increasing task demand and was significantly correlated with a measure of working memory capacity. These results suggest that the complexity of working memory processing may decisively contribute to the exhaustion of resources in PD patients. Increasing complexity may either affect their manipulation ability directly or impede the management of inhibitory control requirements inherent to the task.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239736
DOI: 10.1037/0894-4105.16.4.577
ISI: 000178440800012
Other: P7100
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Title: Neuropsychology
Source Genre: Journal
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Publ. Info: Philadelphia, PA : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 16 (4) Sequence Number: - Start / End Page: 577 - 590 Identifier: ISSN: 0894-4105
CoNE: https://pure.mpg.de/cone/journals/resource/954925559517