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  Model of local temperature changes in brain upon functional activation

Collins, C. M., Smith, M. B., & Turner, R. (2004). Model of local temperature changes in brain upon functional activation. European Journal of Applied Physiology, 97(6), 2051-2055. doi:10.1152/japplphysiol.00626.2004.

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Collins, Christopher M., Author
Smith, M. B., Author
Turner, Robert1, Author              
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1External Organizations, ou_persistent22              

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 Abstract: Experimental results for changes in brain temperature during functional activation show large variations. It is, therefore, desirable to develop a careful numerical model for such changes. Here, a three-dimensional model of temperature in the human head using the bioheat equation, which includes effects of metabolism, perfusion, and thermal conduction, is employed to examine potential temperature changes due to functional activation in brain. It is found that, depending on location in brain and corresponding baseline temperature relative to blood temperature, temperature may increase or decrease on activation and concomitant increases in perfusion and rate of metabolism. Changes in perfusion are generally seen to have a greater effect on temperature than are changes in metabolism, and hence active brain is predicted to approach blood temperature from its initial temperature. All calculated changes in temperature for reasonable physiological parameters have magnitudes <0.12 degrees C and are well within the range reported in recent experimental studies involving human subjects.

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 Dates: 2004
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: eDoc: 511063
ISI: 000224899500004
DOI: 10.1152/japplphysiol.00626.2004
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Title: European Journal of Applied Physiology
  Other : Eur.j.appl.physiol.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag Heidelberg
Pages: - Volume / Issue: 97 (6) Sequence Number: - Start / End Page: 2051 - 2055 Identifier: ISSN: 1439-6319
CoNE: https://pure.mpg.de/cone/journals/resource/954925510395