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  Morphometry of the corpus callosum in patients with questionable and mild dementia

Hensel, A., Wolf, H., Kruggel, F., Riedel-Heller, S. G., Nikolaus, C., Arendt, T., et al. (2002). Morphometry of the corpus callosum in patients with questionable and mild dementia. Journal of Neurology, Neurosurgery & Psychiatry, 73(1), 59-61. doi:10.1136/jnnp.73.1.59.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-C7FF-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-299F-B
Genre: Journal Article

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 Creators:
Hensel, A., Author
Wolf, H., Author
Kruggel, F.1, 2, Author              
Riedel-Heller, S. G., Author
Nikolaus, C., Author
Arendt, T., Author
Gertz, H. J., Author
Affiliations:
1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
2MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: Alzheimer's disease; Dementia; Corpus callosum
 Abstract: Previous studies have shown a reduction in corpus callosum area in advanced Alzheimer's disease, but it is unclear whether callosal atrophy is present in the transitional phase between health and the onset of dementia. The aim of this study was to investigate whether callosal atrophy is present in subjects with questionable and mild dementia and to assess the diagnostic value of callosal measures. In 83 subjects aged 72 to 85 years (33 normal controls, 27 patients with questionable dementia, 23 with mild Alzheimer's disease), magnetic resonance images were recorded and the mid-sagittal callosal area measured. Significant differences were found between normal controls and mild dementia. In subjects with questionable dementia callosal size was intermediate between normal controls and mild Alzheimer's disease. However, callosal measures were unsuitable for diagnostic differentiation between healthy subjects, subjects with questionable dementia, and subjects with mild Alzheimer's disease. The severity of white matter changes did not differ between the groups.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239441
ISI: 000176617100013
Other: P6894
DOI: 10.1136/jnnp.73.1.59
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Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
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Publ. Info: London : British Medical Association
Pages: - Volume / Issue: 73 (1) Sequence Number: - Start / End Page: 59 - 61 Identifier: ISSN: 0022-3050
CoNE: /journals/resource/111085522793000