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  Noradrenergic blockade and numeric working memory in humans

Müller, U., Mottweiler, E., & Bublak, P. (2005). Noradrenergic blockade and numeric working memory in humans. Journal of Psychopharmacology, 19(1), 21-28. doi:10.1177/0269881105048888.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-CD5C-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-45DE-E
Genre: Journal Article

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 Creators:
Müller, Ulrich1, Author              
Mottweiler, Elisabeth2, Author              
Bublak, Peter1, Author              
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1External Organizations, ou_persistent22              
2Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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 Abstract: To investigate the noradrenergic modulation of working memory in humans single doses of two beta-blockers [either 25 mg of propranolol (lipophilic) or 50 mg of atenolol (hydrophilic)] or placebo were administered to young healthy volunteers (16 subjects per drug condition) performing a numerical working memory task that requires either short-term maintenance or maintenance plus manipulation of visually presented four-number sequences. Higher manipulation costs (i.e. process-specific slowing of reaction times in the manipulation conditions compared to the control condition) were observed after propranolol but not after atenolol. The propranolol effect was mainly observed in subjects with low emotional arousal (i.e. low state anxiety rating at baseline). Because both beta-blockers induced a comparable decrease of blood pressure and pulse, the propranolol effect on the 'working component' of working memory is considered to be a central, presumably prefrontal one.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239698
DOI: 10.1177/0269881105048888
Other: P7076
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Title: Journal of Psychopharmacology
  Other : J. Psychopharmacol.
Source Genre: Journal
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Publ. Info: Oxford, UK : Sage Publications, Inc.
Pages: - Volume / Issue: 19 (1) Sequence Number: - Start / End Page: 21 - 28 Identifier: ISSN: 0269-8811
CoNE: https://pure.mpg.de/cone/journals/resource/954925501173