English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing

Gallinat, J., Winterer, G., Herrmann, C. S., & Senkowski, D. (2004). Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing. Clinical Neurophysiology, 115(8), 1863-1874. doi:10.1016/j.clinph.2004.03.013.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D4EF-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-1C43-2
Genre: Journal Article

Files

show Files
hide Files
:
gallinat.pdf (Publisher version), 234KB
 
File Permalink:
-
Name:
gallinat.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Gallinat, J., Author
Winterer, G., Author
Herrmann, Christoph S.1, Author              
Senkowski, Daniel1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

Content

show
hide
Free keywords: Schizophrenia; Gamma; EEG; Event-related potential; Frontal lobe; Binding
 Abstract: OBJECTIVE: Integration of sensory information by cortical network binding appears to be crucially involved in target detection. Studies in schizophrenia using functional and diffusion tensor neuroimaging, event-related potentials and EEG coherence indicate an impairment of cortical network coupling in this disorder. Previous electrophysiological investigations in animals and humans suggested that gamma activity (oscillations at around 40 Hz) is essential for cortical network binding. Studies in medicated schizophrenia provide evidence for a reduced gamma activity in the context of auditory stimulus processing. This is the first investigation of oscillatory activations in the gamma-band in an auditory oddball paradigm in unmedicated schizophrenic patients. METHODS: EEG gamma-band responses (GBRs) of 15 drug-free schizophrenic patients and 15 age- and gender-matched healthy controls were compared. A wavelet transform based on Morlet wavelets was employed for the calculation of oscillatory GBRs. RESULTS: In response to standard stimuli, early evoked GBRs (20-100 ms), which are supposed to reflect auditory cortex activation, did not show significant group differences. However, schizophrenic patients showed reduced evoked GBRs in a late latency range (220-350 ms), particularly after target stimuli. This deficit occurred over right frontal scalp regions. Furthermore, significant correlations were observed between oscillatory GBRs and clinical parameters in schizophrenic patients. CONCLUSIONS: The results are consistent with a relative preserved stimulus processing in the auditory cortex as reflected by the early GBR. The reduced late GBR is compatible with an abnormal interaction within a frontal lobe network, as was postulated by previous neuroimaging studies. SIGNIFICANCE: The present study provides evidence for disturbed processing within frontal cortical regions in unmedicated schizophrenic patients as indicated by reduced evoked EEG GBRs.

Details

show
hide
Language(s): eng - English
 Dates: 2004
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 239549
DOI: 10.1016/j.clinph.2004.03.013
Other: P6966
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Clinical Neurophysiology
  Other : Clin. Neurophysiol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 115 (8) Sequence Number: - Start / End Page: 1863 - 1874 Identifier: ISSN: 1388-2457
CoNE: /journals/resource/954926941726