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  Representational overlap of adjacent fingers in multiple areas of human primary somatosensory cortex depends on electrical stimulus intensity: an fMRI study

Krause, T., Kurth, R., Ruben, J., Schwiemann, J., Villringer, A., Deuchert, M., et al. (2001). Representational overlap of adjacent fingers in multiple areas of human primary somatosensory cortex depends on electrical stimulus intensity: an fMRI study. Brain Research, 899, 36-46. doi:10.1016/S0006-8993(01)02147-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D5A4-1 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-0F5E-8
Genre: Journal Article

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 Creators:
Krause, Tina, Author
Kurth, R., Author
Ruben, J., Author
Schwiemann, J., Author
Villringer, Arno1, Author              
Deuchert, M., Author
Moosmann, M., Author
Brandt, S., Author
Wolf, K., Author
Curio, G., Author
Villringer, Arno1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Sensory systems, Somatosensory cortex and thalamocortical relationships; Functional magnetic resonance imaging; Electrical stimulation; Stimulus intensity; Representational overlap
 Abstract: Functional magnetic resonance imaging (fMRI) was used to examine the influence of non-painful electrical stimulus intensity on the BOLD response in human primary somatosensory cortex (SI). In ten healthy subjects, index and middle finger of the right hand were stimulated separately at two different stimulus intensities. The activated volume of single finger representations as well as the volume of representational overlap of the two activations increased following an increase in stimulus intensity. This effect was seen in two different subdivisions of SI, one in the depth of the central sulcus, presumably corresponding to Brodmann area (BA) 3b, and one on the crown of the postcentral gyrus, presumably corresponding to BA 1/2. Relative overlap (ratio of overlap volume to volume of individual finger representation) was larger in BA 1/2 than in BA 3b. Additionally, in both areas relative overlap increased significantly from low to high stimulus intensity. Relative overlap did not change when different correlation thresholds were employed arguing against an unspecific 'spillover effect'. Analysis of signal intensity time courses indicated that the response difference to high versus low stimulus strength was not present during the initial seconds of stimulation, during which both led to a similar signal intensity increase. Only during the following maintenance level of the response did the response to high stimulus intensity reach a significantly higher plateau level than the one due to low intensity stimulation, an effect which was present in both areas, BA 3b and BA 1/2, respectively.

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 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 511290
Other: P9064
DOI: 10.1016/S0006-8993(01)02147-3
 Degree: -

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Title: Brain Research
  Other : Brain Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 899 Sequence Number: - Start / End Page: 36 - 46 Identifier: ISSN: 0006-8993
CoNE: https://pure.mpg.de/cone/journals/resource/954926250616