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  Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats

Dirnagl, U., Lindauer, U., & Villringer, A. (1993). Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats. Neuroscience Letters, 149(1), 43-46. doi:10.1016/0304-3940(93)90343-J.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D6A1-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-BAB8-B
Genre: Journal Article

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Dirnagl, U.1, Author
Lindauer, U.1, Author
Villringer, Arno1, Author              
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1External Organizations, ou_persistent22              

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Free keywords: Endothelium; Cerebral circulation; Laser-Doppler; Somatosensory stimulation; Rat
 Abstract: We tested the hypothesis that nitric oxide (NO) is a mediator in the coupling of cerebral blood flow to neuronal activation. The production of NO was blocked in anesthetized rats with the NO-synthase inhibitor (l-NA). In controls, vibrissae stimulation for 60 s led to a fast (≤ 2 s), 17% increase in regional cerebral blood flow (rCBF) in the contralateral somatosensory cortex. Systemical (10 mg/kg) as well as topical (10−3 M) application of l-NA reduced the response to stimulation by approximately 50%. Systemical application primarily attenuated the early component of the response, whereas topical application led to an attenuation throughout the whole 60-s stimulation interval. We conclude that NO is involved in rCBF coupling to neuronal activation.

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 Dates: 1993
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 510880
Other: P9149
DOI: 10.1016/0304-3940(93)90343-J
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Title: Neuroscience Letters
Source Genre: Journal
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Pages: - Volume / Issue: 149 (1) Sequence Number: - Start / End Page: 43 - 46 Identifier: -