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  Serial 18F-fluoro-2-deoxy-D-glucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis

Scheid, R., Lincke, T., Voltz, R., von Cramon, D. Y., & Sabri, O. (2004). Serial 18F-fluoro-2-deoxy-D-glucose positron emission tomography and magnetic resonance imaging of paraneoplastic limbic encephalitis. Archives of Neurology, 61(11), 1785-1789. doi:1001/archneur.61.11.1785.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D911-B Version Permalink: http://hdl.handle.net/21.11116/0000-0002-F840-E
Genre: Journal Article

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scheid.pdf (Publisher version), 122KB
 
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 Creators:
Scheid, Rainer1, Author              
Lincke, T.2, Author
Voltz, Raymond2, Author
von Cramon, D. Yves1, Author              
Sabri, Osama2, Author
Affiliations:
1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
2External Organizations, ou_persistent22              

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Free keywords: Encephalitis; Magnetic Resonance Imaging; Tomography, Positron-Emission see Tomography, Emission-Computed; Tomography, Emission-Computed.
 Abstract: OBJECTIVES: To review and expand the existing literature of magnetic resonance imaging (MRI) and positron emission tomography (PET) of paraneoplastic limbic encephalitis (PLE). METHODS: We performed serial MRI and 18F-fluoro-2-deoxy-D-glucose (FDG)-PET in a patient with anti-Ma2-positive PLE. In addition, we reviewed the relevant literature by conducting a search in the Medline database. RESULTS: We found a total of 7 published patient studies of possible or probable PLE containing both MRI and PET data. In 1 of these reports, the diagnosis of PLE can be regarded as proven. The results of the previous studies are controversial. Epileptic activity and inflammation are assumed to be underlying mechanisms of increased FDG uptake. In our study, we found a focal tracer accumulation in the left medial temporal lobe, which increased during the first 9 months of follow-up and corresponded with an increase of serum anti-Ma2 antibody titers. The MRI findings showed a hyperintense signal change in the left medial temporal lobe without contrast enhancement, which remained unchanged over time. CONCLUSIONS: The results of functional and structural imaging in PLE may differ substantially. Results of FDG-PET can demonstrate focal hypermetabolism over a long time, which may indicate therapeutic potential. A prospective study with more patients will be needed to clarify the relevance of PET as a possible outcome measure in PLE. Future studies should include scalp or semi-invasive electroencephalographic recordings during PET acquisition.

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Language(s): eng - English
 Dates: 2004-02-232004-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: eDoc: 239561
Other: P6975
DOI: 1001/archneur.61.11.1785
PMID: 15534190
 Degree: -

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Title: Archives of Neurology
Source Genre: Journal
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Publ. Info: Chicago, IL : American Medical Association
Pages: - Volume / Issue: 61 (11) Sequence Number: - Start / End Page: 1785 - 1789 Identifier: ISSN: 0003-9942
CoNE: https://pure.mpg.de/cone/journals/resource/954922843241