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  Simultaneous detection of changes in perfusion and BOLD contrast

Schwarzbauer, C. (2000). Simultaneous detection of changes in perfusion and BOLD contrast. NMR in Biomedicine, 13(1), 37-42. doi:10.1002/(SICI)1099-1492(200002)13:1<37:AID-NBM611>3.0.CO;2-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-D9CA-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-11E7-4
Genre: Journal Article

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 Creators:
Schwarzbauer, Christian1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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 Abstract: A new functional magnetic resonance imaging (fMRI) technique for simultaneous detection (SIDE) of changes in perfusion and blood oxygenation level dependent (BOLD) contrast is described. Perfusion contrast is generated by using magnetically labeled endogenous water proton spins as a freely diffusible tracer. A single slice-selective inversion pulse is combined with dual echo echo-planar imaging to generate a spin-echo (SE) image sensitive to changes in perfusion and a gradient-echo (GE) image sensitive to changes in both perfusion and BOLD contrast. The SIDE technique was applied to detect functional changes induced by a visual search task. A theoretical analysis is provided to calculate quantitative maps of changes in cerebral blood flow (ΔCBF) and effective transverse relaxation time (ΔT2*) from the corresponding signal changes in the SE and GE images. Since SE an GE images are generated from the same longitudinal magnetization, no errors due to spatial or temporal mismatch can arise in the quantification of ΔCBF and ΔT2*.

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Language(s): eng - English
 Dates: 2000
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
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Title: NMR in Biomedicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Heyden & Son
Pages: - Volume / Issue: 13 (1) Sequence Number: - Start / End Page: 37 - 42 Identifier: ISSN: 0952-3480
CoNE: https://pure.mpg.de/cone/journals/resource/954925574973