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  Spontaneous low-frequency oscillations decline in the aging brain

Schroeter, M. L., Schmiedel, O., & von Cramon, D. Y. (2004). Spontaneous low-frequency oscillations decline in the aging brain. Journal of Cerebral Blood Flow and Metabolism, 24(10), 1183-1191. doi:10.1097/01.WCB.0000135231.90164.40.

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schroeter.pdf (Publisher version), 433KB
 
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 Creators:
Schroeter, Matthias L.1, Author           
Schmiedel, O., Author
von Cramon, D. Yves1, Author           
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1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              

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Free keywords: Aging; Flowmotion; Near-infrared spectroscopy; Spontaneous oscillations; Vasomotion
 Abstract: It is well known that aging leads to a degeneration of the vascular system. Hence, one may hypothesize that spontaneous oscillations decrease in the cerebral microvasculature with aging. Accordingly, the authors investigated the age dependency of spontaneous oscillations in the visual cortex during rest and functional activation. Functional near-infrared spectroscopy was used because it is particularly sensitive to the microvasculature. Visual stimulation led to an increase of oxyhemoglobin, total hemoglobin, and a decrease of deoxyhemoglobin, without any influence of age. Peaks of normalized power spectral density were detected for spontaneous low-frequency (0.07 to 0.11 Hz) and very-low-frequency (0.01 to 0.05 Hz) oscillations, with a higher amplitude for oxyhemoglobin than for deoxyhemoglobin. Spontaneous low-frequency oscillations of oxyhemoglobin and deoxyhemoglobin declined strongly with aging during both rest and visual stimulation. Reduction of spontaneous low-frequency oscillations might indicate a declining spontaneous activity in microvascular smooth muscle cells, in conjunction with an increased vessel stiffness with aging.

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Language(s): eng - English
 Dates: 2004
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 239675
Other: P7057
DOI: 10.1097/01.WCB.0000135231.90164.40
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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 24 (10) Sequence Number: - Start / End Page: 1183 - 1191 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202