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  Spontaneous slow hemodynamic oscillations are impaired in cerebral microangiopathy

Schroeter, M. L., Bücheler, M. M., Preul, C., Scheid, R., Schmiedel, O., Guthke, T., et al. (2005). Spontaneous slow hemodynamic oscillations are impaired in cerebral microangiopathy. Journal of Cerebral Blood Flow and Metabolism, 25(12), 1675-1684. doi:10.1038/sj.jcbfm.9600159.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-DB63-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7DD2-5
Genre: Journal Article

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 Creators:
Schroeter, Matthias L.1, Author              
Bücheler, Markus M.1, Author              
Preul, Christoph1, Author              
Scheid, Rainer1, Author              
Schmiedel, O., Author
Guthke, Thomas2, Author              
von Cramon, D. Yves1, Author              
Affiliations:
1Department Cognitive Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634563              
2External Organizations, ou_persistent22              

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 Abstract: Small-vessel disease or cerebral microangiopathy (CMA) is a common finding in elderly people. It is related to a variety of vascular risk factors and may finally lead to subcortical ischemic vascular dementia. Because vessel stiffness is increased, we hypothesized that slow spontaneous oscillations are reduced in cerebral hemodynamics. Accordingly, we examined spontaneous oscillations in the visual cortex of 13 patients suffering from CMA, and compared them with 14 age-matched controls. As an imaging method we applied functional near-infrared spectroscopy, because it is particularly sensitive to the microvasculature. Spontaneous low-frequency oscillations (LFOs) (0.07 to 0.12 Hz) were specifically impaired in CMA in contrast to spontaneous very-low-frequency oscillations (0.01 to 0.05 Hz), which remained unaltered. Vascular reagibility was reduced during visual stimulation. Interestingly, changes were tightly related to neuropsychological deficits, namely executive dysfunction. Vascular alterations had to be attributed mainly to the vascular risk factor arterial hypertension. Further, results suggest that the impairments might be, at least partly, reversed by medical treatment such as angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers. Results indicate that functional near-infrared spectroscopy may detect changes in the microvasculature due to CMA, namely an impairment of spontaneous LFOs, and of vascular reagibility. Hence, CMA accelerates microvascular changes due to aging, leading to impairments of autoregulation.

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Language(s): eng - English
 Dates: 2005
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 265641
Other: P7170
DOI: 10.1038/sj.jcbfm.9600159
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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 25 (12) Sequence Number: - Start / End Page: 1675 - 1684 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202