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  Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: A 6-[18F]fluoro-L-dopa PET study

Ito, K., Nagano-Saito, A., Kato, T., Arahata, Y., Nakamura, A., Kawasumi, Y., et al. (2002). Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: A 6-[18F]fluoro-L-dopa PET study. Brain, 125, 1358-1365. doi:10.1093/brain/awf134.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-DC5C-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-293C-B
Genre: Journal Article

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 Creators:
Ito, Koji, Author
Nagano-Saito, A., Author
Kato, T., Author
Arahata, Y., Author
Nakamura, Akinori1, Author              
Kawasumi, Y., Author
Hatano, K., Author
Abe, Y., Author
Yamada, T., Author
Kachi, T., Author
Brooks, D. J., Author
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: 6‐[18F]fluoro‐l‐dopa; Positron emission tomography; Parkinson’s disease; Parkinson’s disease with dementia
 Abstract: We investigated the relative differences in dopaminergic function through the whole brain in patients with Parkinson’s disease without dementia (PD) and with dementia (PDD) using 6‐[18F]fluoro‐l‐dopa (18F‐dopa) PET and a voxel‐by‐voxel analysis. The 10 PD and 10 PDD patients were equivalently disabled, having mean scores of 3.2 ± 0.6 and 3.2 ± 0.7, respectively, on the Hoehn and Yahr rating scale. 18F‐dopa influx constant (Ki) images of those patients and 15 normal age‐matched subjects were transformed into standard stereotactic space. The significant differences between the groups (expressed in mean regional Ki values) were localized with statistical parametric mapping (SPM) on a voxel‐by‐voxel basis. Compared with the normal group, SPM localized declines of the 18F‐dopa Ki bilaterally in the putamen, the right caudate nucleus and the left ventral midbrain for the PD group (P < 0.01, corrected). Com pared with the normal group, the PDD group showed reduced 18F‐dopa Ki bilaterally in the striatum, midbrain and anterior cingulate area (P < 0.01, corrected). A relative difference in 18F‐dopa uptake between PD and PDD was the bilateral decline in the anterior cingulate area and ventral striatum and in the right caudate nucleus in the PDD group (P < 0.001, corrected). Accordingly, we conclude that dementia in PD is associated with impaired mesolimbic and caudate dopaminergic function.

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Language(s): eng - English
 Dates: 2002
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: eDoc: 239225
Other: P6749
DOI: 10.1093/brain/awf134
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Title: Brain
  Other : Brain
Source Genre: Journal
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Publ. Info: London : Macmillan
Pages: - Volume / Issue: 125 Sequence Number: - Start / End Page: 1358 - 1365 Identifier: ISSN: 0006-8950
CoNE: /journals/resource/954925385135