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  Striatal [I-123]beta-CIT SPECT and prefrontal cognitive functions in Parkinson's disease

Müller, U., Wächter, T., Barthel, H., Reuter, M., & von Cramon, D. Y. (2000). Striatal [I-123]beta-CIT SPECT and prefrontal cognitive functions in Parkinson's disease. Journal of Neural Transmission, 107(3), 303-319. doi:10.1007/s007020050025.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-DC64-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7DF9-F
Genre: Journal Article

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 Creators:
Müller, Ulrich1, Author              
Wächter, T.1, Author              
Barthel, H., Author
Reuter, Martin, Author
von Cramon, D. Yves1, Author              
Affiliations:
1MPI of Cognitive Neuroscience (Leipzig, -2003), The Prior Institutes, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634574              

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Free keywords: Parkinson's disease; [123I]beta-CIT; SPECT; Working memory; cCognition; Prefrontal
 Abstract: Twenty non-demented patients with idiopathic Parkinson's disease (PD) underwent single photon emission computed tomography (SPECT) with [123I]β-CIT to further investigate the contribution of nigrostriatal dysfunction to cognitive and motor deficits. Compared to matched controls PD patients showed normal verbal intelligence, short-term memory and phasic alertness. There were significant (p < 0.05) deficits in tests of verbal working memory (digit ordering, reading span), strategic memory (story recall) and executive functions (card sorting), indicating a "prefrontal" cognitive deficit. Significant (p < 0.05) correlations were observed between dopamine transporter (DAT) density in the putamen and motor deficits as well as between DAT density in both striatal compartments (head of the caudate nucleus and putamen) and prefrontal functioning. Age was a major contributing factor to both cognitive status and nigrostriatal integrity as measured by [123I]β-CIT SPECT. These results support the view that the striatum is part of a neuronal network that is mediating prefrontal cognitive functions.

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Language(s): eng - English
 Dates: 2000
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 239671
ISI: 000086025600005
Other: P7053
DOI: 10.1007/s007020050025
 Degree: -

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Title: Journal of Neural Transmission
  Other : J. Neural Transm.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Wien : Springer-Verlag.
Pages: - Volume / Issue: 107 (3) Sequence Number: - Start / End Page: 303 - 319 Identifier: ISSN: 0300-9564
CoNE: https://pure.mpg.de/cone/journals/resource/991042725899232