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  Subcortical lesions after transient thread occlusion in the rat: T2-weighted magnetic resonance imaging findings without corresponding sensorimotor deficits

Wegener, S., Weber, R., Ramos-Cabrer, P., Uhlenkueken, U., Wiedermann, D., Kandal, K., et al. (2005). Subcortical lesions after transient thread occlusion in the rat: T2-weighted magnetic resonance imaging findings without corresponding sensorimotor deficits. Journal of Magnetic Resonance Imaging, 21(4), 340-346. doi:10.1002/jmri.20270.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-DCC6-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-D59F-B
Genre: Journal Article

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Wegener, S., Author
Weber, R., Author
Ramos-Cabrer, P., Author
Uhlenkueken, U., Author
Wiedermann, D., Author
Kandal, K., Author
Villringer, Arno1, Author              
Hoehn, M., Author
Affiliations:
1External Organizations, ou_persistent22              

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Free keywords: Animal models; Functional tests; Ischemia; Magnetic resonance imaging; Middle cerebral artery occlusion; Sensorimotor behavior
 Abstract: Purpose: To investigate infarct evolution and functional consequences of exclusive subcortical or cortico-subcortical strokes, transient middle cerebral artery occlusion (MCAO) was conducted in Wistar rats. Materials and Methods: MCAO was induced in male Wistar rats (260-300 g) for 60 minutes. Lesion volumes and absolute T2 times on magnetic resonance imaging (MRI) were assessed 1 and 14 days after MCAO using a 4.7-T MRI animal scanner in conjunction with functional testing (adhesive tape removal, cylinder test, and ledged beam walking). Results: Functional test scores were not distinguishable between sham-operated animals (N = 5) and those with exclusive caudoputaminal infarct (N = 8; group cp), but showed significant deficits in animals with cortico-subcortical infarction (N = 10; group cp+). The cp group had lower absolute T2 times and a more pronounced reduction in T2 lesion volume over time than the subcortical component in the cp+ group. There was no correlation of T2lesion size or absolute T2 times and functional impairment in either group. Conclusion: When judged from functional tests alone, subcortical ischemic lesions may not be diagnosed reliably. Furthermore, T2-weighted (T2-W) MRI does not well anticipate functional deficits in primarily striatal lesions.

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 Dates: 2005-03-18
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 511640
Other: P9021
DOI: 10.1002/jmri.20270
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Pages: - Volume / Issue: 21 (4) Sequence Number: - Start / End Page: 340 - 346 Identifier: -