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  The effects of COMT (Val108/158Met) and DRD4 (SNP –521) dopamine genotypes on brain activations related to valence and magnitude of rewards

Camara, E., Krämer, U. M., Cunillera, T., Marco-Pallares, J., Cucurell, D., Nager, W., et al. (2010). The effects of COMT (Val108/158Met) and DRD4 (SNP –521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cerebral Cortex, 20(8), 1985-1996. doi:10.1093/cercor/bhp263.

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https://doi.org/10.1093/cercor/bhp263 (Publisher version)
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 Creators:
Camara, Estela1, 2, Author
Krämer, Ulrike M.2, Author
Cunillera, Toni1, Author
Marco-Pallares, Josep2, Author
Cucurell, David1, Author
Nager, Wido2, 3, Author
Mestres-Misse, Anna2, 4, 5, Author           
Bauer, Peter6, Author
Schüle, Rebecca7, Author
Schöls, Ludger7, Author
Tempelmann, Claus8, Author
Rodriguez-Fornells, Antoni1, 9, Author
Münte, Thomas F.2, 10, Author
Affiliations:
1Department of Psicologia Basica, Faculty of Psychology, University of Barcelona, Spain, ou_persistent22              
2Department of Neuropsychology, Otto von Guericke University, Magdeburg, Germany, ou_persistent22              
3Department of Neurology, Medical School Hannover, Germany, ou_persistent22              
4Minerva Research Group Neurocognition of Rhythm in Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634560              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
6Department of Medical Genetics, University of Tübingen, Germany, ou_persistent22              
7Department of Clinical Neurogenetics, Hertie-Institut für Klinische Hirnforschung, University of Tübingen, Germany, ou_persistent22              
8Department of Neurology, Otto von Guericke University, Magdeburg, Germany, ou_persistent22              
9Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain , ou_persistent22              
10Center for Behavioral Brain Science, Magdeburg, Germany, ou_persistent22              

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Free keywords: dopamine; fMRI; polymorphism; reward; ventral striatum
 Abstract: People's sensitivity to reinforcing stimuli such as monetary gains and losses shows a wide interindividual variation that might in part be determined by genetic differences. Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP-521 polymorphism of the dopamine D4 receptor. Participants took part in a gambling paradigm featuring unexpectedly high monetary gains and losses in addition to standard gains/losses of expected magnitude while undergoing functional magnetic resonance imaging at 3 T. Valence-related brain activations were seen in the ventral striatum, the anterior cingulate cortex, and the inferior parietal cortex. These activations were modulated by the COMT polymorphism with greater effects for valine/valine participants but not by the D4 receptor polymorphism. By contrast, magnitude-related effects in the anterior insula and the cingulate cortex were modulated by the D4 receptor polymorphism with larger responses for the CC variant. These findings emphasize the differential contribution of genetic variants in the dopaminergic system to various aspects of reward processing. The Author © 2009. Published by Oxford University Press. All rights reserved.

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Language(s): eng - English
 Dates: 2009-12-272010-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 512145
Other: P11428
DOI: 10.1093/cercor/bhp263
PMID: 20038544
 Degree: -

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Funding organization : Volkswagen-Foundation
Project name : -
Grant ID : -
Funding program : -
Funding organization : Alexander von Humboldt Foundation
Project name : -
Grant ID : SFB779/ A5
Funding program : -
Funding organization : German Research Foundation (MPG)

Source 1

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 20 (8) Sequence Number: - Start / End Page: 1985 - 1996 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440